Which women must undergo Down syndrome screening during pregnancy?

In life, many people are very worried about women's health during pregnancy. Down syndrome screening is a concern for many people, so we don't know what this is all about. In order to protect women's health during pregnancy, we need to understand which women need to do this examination. So which women must undergo Down syndrome screening during pregnancy? Let's take a look at the authoritative experts' detailed answers to this question based on their years of clinical experience.

Women need to be screened for Down syndrome during pregnancy. Down syndrome, also known as trisomy 21, is a congenital intellectual disability or Down syndrome, which is an autosomal abnormality and the most common chromosomal disease in children. The incidence rate in live births is about 1/(600-800). The older the mother is, the higher the incidence rate of the disease. 60% of children die or have miscarriage in the early fetal stage.

Among them, Down syndrome includes a series of genetic diseases, the most representative of which is the trisomy of the 21st pair of chromosomes, which can lead to severe deformities including learning disabilities, intellectual disabilities and disability. _1

TSt% The incidence of Down syndrome has no direct relationship with race, living standards, etc. It is estimated that one in every 660 newborns suffers from Down syndrome, making it the most common chromosomal mutation. Older primiparas increase the risk of having a baby with Down syndrome. Between 20 and 24 years of age, the prevalence is 1/1490, at 40 years of age it is 1/106, and at 49 years of age it is 1/11. The reason is that as the maternal age increases, the phenomenon of chromosome nondisjunction will increase during egg formation. On the other hand, however, approximately 80% of infants with the syndrome are born to mothers under 35 years of age. This is related to the higher pregnancy rate among women under 35 years old.

There are also cases where the extra chromosomes come from the father, and the ratio of paternal to maternal causes is 1:4. Families at high risk for the disease are often offered genetic counseling and genetic testing such as amniocentesis.

1. Aged over 35 years old.

2. The embryo stops developing or the fetus stops growing for unknown reasons.

3. There is a history of giving birth to an abnormal child, such as giving birth to a child with hydrocephalus.

4. Prepartum hemorrhage. Vaginal bleeding during pregnancy.

5. There is a history of contact with harmful substances in the early stages of pregnancy.

6. You have a history of taking medication in early pregnancy, but you don’t know whether this medication has any effect.

7. There is a family history. Although the pregnant woman herself has no previous medical history, she does have a clear family history, so she should undergo Down syndrome screening during her first pregnancy.

The above is a brief introduction to "Which women must undergo Down syndrome screening during pregnancy". We have learned the general situation of women undergoing Down syndrome screening. We often encounter various physical conditions in our lives, but what we need is to treat these problems positively and deal with them well. As long as we have this mentality, we can have a better life. Finally, I wish everyone can stay away from diseases and live a happy and healthy life!