How to treat polyfollicular ovary

Polyfollicular ovary is a female disease. Today's environmental pollution is slowly eroding our health, especially some female diseases, which have too much impact on women. Some foods bought on the market have no safety guarantee at all. Polyfollicular ovary is a common disease and must be taken seriously. Let us learn about the treatments for polyfollicular ovary.

1. Obesity and insulin resistance

Increase exercise to lose weight, correct endocrine and metabolic disorders aggravated by obesity, reduce insulin resistance and hyperinsulinemia, reduce IGF-1, increase IGfBP-1, and at the same time increase SHBG to reduce free androgen levels. Losing weight can restore ovulation in some obese women with PCOS and prevent the occurrence of type 2 diabetes and cardiovascular disease. Metformin treatment can be used for patients with or without diabetes. It can effectively reduce body weight, improve insulin sensitivity, lower insulin levels, reduce hair loss, and even restore menstruation (25%) and ovulation. Since obesity and insulin resistance are the main causes of PCOS, any drug that can reduce weight and increase insulin sensitivity can treat this syndrome.

2. Drug-induced ovulation

(1) Clomiphene is the drug of choice for PCOS, with an ovulation rate of 60% to 80% and a pregnancy rate of 30% to 50%. Clomiphene competes with endogenous estrogen receptors at the hypothalamus-pituitary level, inhibits estrogen negative feedback, increases the pulse frequency of GnRH secretion, and thus adjusts the secretion ratio of LH and FSH. Clomiphene also directly stimulates the ovaries to synthesize and secrete estrogen. After taking this drug, the ovaries may enlarge due to overstimulation (13.6%), vasodilation may cause hot flashes (10.4%), abdominal discomfort (5.5%), blurred vision (1.5%), or side effects such as rash and mild hair loss may occur.

During treatment, it is necessary to record the basal body temperature of the menstrual cycle, monitor ovulation, or measure serum progesterone and estradiol to confirm whether ovulation occurs and guide the adjustment of the dosage for the next treatment course. If there is still no ovulation or conception after 6 to 12 months of clomiphene treatment, clomiphene plus HCG or glucocorticoids, bromocriptine or HMG, FSH, GnRH, etc. can be given.

(2) Combination of clomiphene and human chorionic gonadotropin (HCG): HCG should be added on the 7th day after discontinuation of clomiphene.

(3) The effect of glucocorticoids combined with clomiphene is based on its ability to inhibit excessive androgen secretion from the ovaries or adrenal glands. Dexamethasone or prednisone is usually used. The effective rate within 2 months is 35.7%, and the ovarian function of patients with amenorrhea and anovulation is restored to a certain extent. When clomiphene is ineffective in inducing ovulation, dexamethasone can be added during the treatment cycle.

The above are the treatment methods for polyfollicular ovary. This disease has a great impact on women. Because this condition can also lead to symptoms of female infertility, it is for the health of women. Women should pay special attention to some treatments for this disease. Only reasonable treatments can help us get rid of the disease as soon as possible.