What is blocking antibody deficiency?

Some of you may have heard of the symptoms of blocking antibody deficiency, but there are definitely not many people who really understand blocking antibody deficiency. After all, blocking antibody deficiency is not a common symptom of ours. However, due to the great harm of blocking antibody deficiency, it is still necessary for us to learn more about blocking antibody deficiency. Below we will introduce to you what blocking antibody deficiency is.

It was like she was under a "miscarriage curse". She would miscarry quickly after becoming pregnant. She had six miscarriages in three years, each time at the age of two or three months. Even though she was very careful after finding out she was pregnant, she still couldn't keep the baby... The genes of the husband and wife were similar, and they lacked blocking antibodies. Only by finding out the cause could the mystery of the curse be solved.

Painful experience: six miscarriages in three years Ms. Qin's husband introduced the situation in recent years: We got married three years ago, and my wife became pregnant right after the marriage. The whole family was very happy at that time. But not long after, she had a miscarriage. At first we thought it was because I wasn’t careful after I became pregnant and she must have bumped into something on her stomach, but the next few years made us completely despair, as my wife had miscarriages every time she got pregnant. Afterwards, we conducted a series of physical examinations, but strangely, the results were all normal. There was nothing abnormal with the man's sperm and chromosomes, and the woman's uterine cavity and gynecological endocrine system. Many people told us that the early stages of pregnancy are a dangerous period and that we need to lie still, so my wife simply quit her job and stayed in bed, but she still couldn’t escape the fate of miscarriage, and we were about to collapse.

Found the cause: Ms. Qin has been searching for the answer for many years as to why she always had miscarriages: was it caused by "genetic similarity"? After many twists and turns, they finally found the "culprit" that caused the miscarriage - the lack of blocking antibodies. In simple terms, it is a disorder of the mother's immune function, which cannot produce blocking antibodies. As a result, the immune function receives wrong information during the identification process, and regards the fetus in the uterus as a "foreign invader", thereby rejecting the fetus.

Normally, a woman's blocking antibodies will turn positive after she becomes pregnant, thereby protecting the fetus from miscarriage. However, Ms. Qin and her husband have similar HLA genes and cannot produce blocking antibodies, or produce too few antibodies, which will reduce the protection of the embryo and increase the chance of miscarriage.

Nurturing hope: Spouse leukocyte immunotherapy For women with recurrent miscarriages, it is important to check their blocking antibodies. Once the blocking antibodies in the body are found to be negative, timely treatment is required.

For those with negative blocking antibodies, spouse's leukocyte immunotherapy is mainly used to increase the level of blocking antibodies in patients with recurrent spontaneous abortion, and then wait until the antibody test is positive before getting pregnant, so that the pregnancy can be successful. During the treatment, medical staff drew a certain amount of peripheral blood from the husband for centrifugal sedimentation to separate and culture lymphocytes, and then infused them back into the skin of his wife's forearm. After pregnancy, another course of consolidation treatment should be carried out to ensure stability during the pregnancy. Generally, one course of treatment consists of 4 treatments, with a 2-week interval between each treatment.

In the above article, we introduced a relatively rare symptom, that is, blocking antibody deficiency. We know that blocking antibody deficiency is very harmful, so we recommend that our female friends should do a good job in preventing blocking antibody deficiency.