What is mild atypical hyperplasia of the cervix?

You must have heard of cervical cancer! So, do you know what causes the final development of this disease? Let’s find out together. The early stage of cervical cancer is the appearance of atypical hyperplasia of the cervical epithelium. In the early stages, we all knew that it could be cured through force therapy or surgical resection. However, if we ignore it in the early stages, it will tend to develop into cervical cancer over time.

Atypical hyperplasia of the cervical epithelium may lead to cervical cancer. However, cervical lesions are not a contraindication to childbirth, but this factor needs to be taken into consideration when choosing the method of delivery at full term. So if you want to have children, you can go ahead and have them, but your wife's cervical lesions must be strictly checked regularly. The lesions will likely accelerate after pregnancy. If it is confirmed that the atypical hyperplasia has progressed to a severe stage, surgical treatment will be required.

Atypical hyperplasia (dysplasia, atypical hyperplasia) is a term in pathology, mainly referring to the abnormal proliferation of epithelial cells, characterized by the proliferating cells being of different sizes and shapes, with large and darkly stained nuclei, an increased nuclear-cytoplasmic ratio, and an increased number of nuclear divisions but mostly normal nuclear division images. The cells are arranged in a disordered manner, the number of cell layers increases, and the polarity disappears. However, pathological nuclear division is generally not seen; it can occur in the epithelium covering the surface of the skin or mucous membranes, or in the glandular epithelium.

It is generally believed that the development from normal cells to tumor cells must go through a process: normal - hyperplasia - atypical hyperplasia - carcinoma in situ - invasive cancer. Atypical hyperplasia is the intermediate station from benign changes to malignant changes, and the key point from quantitative change to qualitative change. Therefore, atypical hyperplasia is called "precancerous lesions." Atypical hyperplasia is a morphological change of precancerous lesions. The proliferating epithelial cells show a certain degree of atypia in morphology and structure, but it is not enough to be diagnosed as cancer.

2 Grading of atypical hyperplasia

Atypical hyperplasia often occurs in squamous epithelium, but can also occur in glandular epithelium. Atypical squamous epithelial hyperplasia can be divided into three grades: mild, moderate, and severe according to the degree of atypia and/or the scope of involvement. If this change involves 1/3 of the lower part of the epithelium, it is mild atypical hyperplasia; if it involves more than 1/3-2/3 of the lower part of the epithelium, it is severe atypical hyperplasia; if it involves the entire layer of the epithelium, it has become carcinoma in situ. Mild to moderate atypical hyperplasia can return to normal after the cause is eliminated. Severe atypical hyperplasia is difficult to reverse and often turns into cancer. Intraepithelial neoplasia includes atypical hyperplasia and carcinoma in situ. Mild, moderate and severe atypical hyperplasia are called intraepithelial neoplasia grade I, II and III respectively, and carcinoma in situ is also included in intraepithelial neoplasia grade III. The above-mentioned precancerous diseases and lesions often become cancerous through atypical hyperplasia.

For mild atypical hyperplasia, whether it can be cured depends mainly on the severity of the lesion. If the doctor tells the patient that the lesion is mild, it usually does not require treatment, but we must go to the hospital for regular checkups to prevent the lesion from occurring again. If the diagnosis is severe hyperplasia, then we need to pay attention to it. Due to the limited defense line of the body, it is difficult to eliminate it by one's own immunity, so we need to undergo surgical treatment.