The high single item of CA125 is not very meaningful

Ca125 is a glycoprotein and also a tumor marker. In normal people, blood cell CA125 is maintained at a low level. Under normal circumstances, the blood cell CA125 value is below 35U/ml (the CA125 value will increase during menstruation and pregnancy, which is normal). CA125 also exerts its influence on some endocrine systems. For example, it can serve as a component of cell mucus and participate in lubrication; it can also serve as a mechanical barrier and adhesion molecule to resist foreign matter and infection.

1. The high practical significance of CA125 single project is not great

CA125 is a key indicator used in the diagnosis and treatment of ovarian cancer. The standard value is 0-35U/ml. If it is higher, the common cause is uterine and ovarian tumors, but in many cases it may also be chronic ovarian disease or inflammation. Such as uterine and ovarian chocolate cysts, pelvic inflammatory disease, pelvic tuberculosis, endometriosis, etc. Therefore, once the CA125 single item is high, it is not possible to determine the location and type of the disease, so there is no need to be too nervous. You can listen to the advice of the attending physician and do further detailed examinations to rule out the possibility of ovarian cancer. There are still many people who have high scores in individual projects of CA125, so there is no need to panic too much.

An increase in CA125 (excluding pregnancy and menstruation) may indicate a tumor. CA125 is often used to detect ovarian epithelial cancer. In addition, the CA125 values ​​of patients with adenomyosis, chocolate cysts, uterine fibroids, etc. are always higher than those of ordinary people. Therefore, when many patients with adenomyosis are examined, in addition to B-ultrasound examination, a CA125 auxiliary examination is also required.

2. In what diseases does CA125 generally increase?

Malignant transformation: Studies have found that CA125 levels increase in most patients with epithelial ovarian cancer pathology. In addition, CA125 may also increase in some other cancers. For example, gastric cancer, pancreatic cancer, breast cancer and other diseases. Benign diseases: In addition to the above malignant diseases, CA125 may also increase in some benign diseases, such as adenomyosis, chocolate cysts, tuberculous pleuroperitoneitis and pelvic inflammatory disease.