Can polycystic ovary be treated with gonadotropin?

The harm that infertility brings to female patients is difficult to describe in words. If infertility leads to divorce, the harm suffered by women will be even greater. Polycystic ovary is a common gynecological disease that can cause women to suffer from infertility. If patients can actively receive treatment after being ill, there is still a possibility of pregnancy. So, can polycystic ovary be treated with gonadotropin?

Indications

1. Used in combination with chorionic gonadotropin or clomiphene to treat anovulatory infertility. It can be used for patients with anovulation due to insufficient secretion of pituitary gonadotropin or hypothalamic gonadotropin-releasing hormone. It is currently generally recommended for use in cases where ovulation induction with clomiphene or bromocriptine is ineffective. When used in combination with clomiphene, the dosage of this product can be reduced by about 50% and the incidence of ovarian hyperstimulation can be reduced.

2. It is also used for primary or secondary amenorrhea, male sperm deficiency and ovarian function tests, etc.

Clinical Application

Ovulation induction in adults: On the 3rd to 5th day of withdrawal bleeding or menstruation, inject 2 vials intramuscularly per day for 7 consecutive days, and monitor the changes in follicles with B-ultrasound. When the follicles reach 20mm and the urinary estrogen reaches 100-200μg in 24 hours, inject HCG 5000-10000 units on the day after the last use of this product to induce ovulation. If pregnancy fails, the treatment can be repeated for 2 cycles. If the urinary estrogen exceeds 200μg in 24 hours, HCG should not be used to avoid overstimulation. If ovulation still does not occur, the dosage can be increased to 3-4 vials per day under B-ultrasound monitoring or urinary estrogen monitoring. For most patients, the treatment course is within 10 days. If FSH alone is used, the initial dose is 150 units, injected intramuscularly once a day. For the treatment of male hypopituitarism and spermatogenesis stimulation, 3 times a week, intramuscular injection of FSH 75 units or 50 units and LH 75 units or 150 units.

Adverse Reactions

Overdose can cause ovarian hyperstimulation syndrome, ovarian enlargement, ovarian cyst rupture, multiple pregnancy and miscarriage. Some patients may experience ascites, pleural effusion, arterial thromboembolism, fever, etc.

Precautions

Because the rate of multiple pregnancy may be high, premature newborns are also more common. Common ovarian hyperstimulation syndrome, mild cases include fullness or pain in the stomach and pelvis, and mild enlargement of the ovaries, which disappears in 7 to 10 days. Moderate and severe cases may develop ascites and pleural effusion, and the ovaries may enlarge to 10 cm in diameter. The patient should be hospitalized to avoid irreversible electrolyte imbalance or even death. If symptoms such as abdominal pain, bloating, nausea, vomiting, and diarrhea occur during treatment, the medication should be stopped immediately. The use of this product often increases the risk of arterial embolism.

Contraindications

It is contraindicated in patients with unexplained abnormal vaginal bleeding during ovulation induction, uterine fibroids, ovarian cysts or enlargement, adrenal insufficiency, and thyroid insufficiency.

It is contraindicated for patients with pregnancy, ovarian insufficiency (high levels of gonadotropin in urine), polycystic ovaries, intracranial lesions (including pituitary tumors), hormone-sensitive malignant tumors, etc.

Use with caution in patients with asthma, heart disease, epilepsy, migraine, renal impairment, pituitary hypertrophy or tumors.

Note: The above content is for introduction only. Drug use must be carried out in a regular hospital under the guidance of a doctor.