How much is the human chorionic gonadotropin level when not pregnant?

Human chorionic gonadotropin is a very important hormone in our body. This disease determines whether people are normal or pregnant. Many women know that the test results of human chorionic gonadotropin after pregnancy are different from those of normal times. When not pregnant, human chorionic gonadotropin is within the normal range. When people are pregnant, they know whether they are pregnant through this test. So what is the human chorionic gonadotropin level when not pregnant?

Human chorionic gonadotropin (HCG) αβ is synthesized by syncytial trophoblasts. A glycoprotein hormone with a molecular weight of 36,700, composed of two different subunits, α and β. The α subunit is basically similar to the FSH (follicle stimulating hormone), LH (luteinizing hormone) and TSH (thyroid stimulating hormone) secreted by the pituitary gland, so they can cross-react with each other, while the structures of the β subunits are different. β-HCG is similar in structure to β-LH, but the last 24 amino acids are not present in β-LH. Therefore, the characteristics of the β-HCG subunit are used clinically to make specific antibodies for diagnosis to avoid interference from β-LH. HCG begins to be secreted on the 6th day after fertilization and can be detected in the serum and urine of pregnant women on the 7th day after fertilization. It can be used for the diagnosis of early pregnancy. The serum concentration reaches a peak at 8-10 weeks of pregnancy, about 50-100 kU/L, and then decreases rapidly after 10 days. In mid- and late pregnancy, the blood concentration is only 10% of the peak. It lasts until delivery and usually disappears 1-2 weeks after delivery.

(1) However, the α-subunit is common to all anterior pituitary hormones.

(2) The β-subunit is specific to human chorionic gonadotropin.

Complete human chorionic gonadotropin is produced entirely by the syncytiotrophoblast of the placental chorion.

Normal reference value:

(1) The normal value of blood human chorionic gonadotropin is <10μg/L.

(2) The normal value of β-HCG is <3.1μg/L.

Functions: (1) It has the functions of FSH and LH, maintaining the life of the menstrual corpus luteum and making it enlarge into the corpus luteum of pregnancy; (2) It promotes the aromatization of androgens into estrogens and stimulates the formation of progesterone;

(3) Inhibit the stimulation of lymphocytes by plant lectins. Human chorionic gonadotropin can be adsorbed on the surface of trophoblast cells to prevent embryonic trophoblast cells from being attacked by maternal lymphocytes;

(4) LH-like function: before the fetal pituitary gland secretes LH, it stimulates the fetal testicles to secrete testosterone to promote male sexual differentiation; it can also promote gonadal development, and in men, it can stimulate the activity of interstitial cells in the testicles and increase the secretion of androgen (testosterone). It is of great significance for the treatment of male patients with combined pituitary deficiency. It can not only promote gonadal development and the secretion of male hormones, but also promote the development of secondary sexual characteristics.

(5) Can bind to the TSH receptors of maternal thyroid cells and stimulate thyroid activity.

Changes: Human chorionic gonadotropin enters the maternal blood after fertilization and proliferates rapidly until the 8th week of pregnancy, then slowly decreases in concentration until the 18th to 20th week, and then remains stable. Generally, an increase in the level of human chorionic gonadotropin to at least 2.5MoM is associated with Down syndrome. However, the actual average level of complete human chorionic gonadotropin in the maternal blood of DS patients is only 1.3MoM, which cannot clearly identify DS patients. The human chorionic gonadotropin-related molecules used for DS examination are free b-hCG and high sugar hCG (H-hCG). H-hCG-related molecular screening for Down syndrome is sensitive and can be performed using urine sampling. The plasma H-hCG concentration in mothers of DS children was 9.9-fold higher than that in non-infected pregnant women.

You can refer to this normal value to see whether your index is high or low. If it is high, then you may be pregnant. If it is within the normal value, then it means that you are not pregnant yet. If you want to know whether you are pregnant or not, the method is actually very simple. Just go to the hospital in time for a routine urine test and you will know. You can also choose to use test strips for testing.