Diagnosis and treatment of cholestasis in pregnant women

Everyone is unfamiliar with cholestasis. The symptoms of this disease are yellowing and even itching. Most of the cases occur in newborns and pregnant women. The severity of jaundice determines the severity of the itching. In severe cases, itching will occur all over the body. If you encounter these problems, you must seek treatment in time. The following are the treatment methods introduced to you.

Symptoms and signs

(1) Generalized itching first occurs in the middle and late stages of pregnancy and is more severe at night, with no specific rash.

(2) There is no history of hepatitis or contact with the patient, and there are often no gastrointestinal symptoms or liver enlargement, and no percussion pain or tenderness.

(3) Jaundice only occurs during pregnancy and disappears after the pregnancy ends. Pruritus occurs before jaundice appears. Jaundice is usually mild or moderate, much milder than itching.

Diagnostic tests

1. Laboratory examination (1) Serum total bilirubin is elevated and may reach 68-88.5 μmol/L (4-5 mg/dL), but rarely exceeds 85.5 μmol/L. (2) Elevated serum bile acid levels, which can be 10 times higher than normal, are a specific sign of this disease. (3) Increased alkaline phosphatase activity. (4) Transaminase may be slightly or moderately elevated.

The above is an introduction to the treatment and diagnosis methods of cholestasis in pregnant women. Pregnant mothers who have this disease should receive treatment in time. Patients with severe jaundice will affect the replicated fetus. Early treatment is the best choice.