How to treat small follicles quickly

Small follicle development and follicular hypoplasia are the same. Small follicle development means that in the late follicular stage, the follicle growth cannot reach the size of a mature follicle, and has poor function and insufficient estrogen secretion. Many women who have not gotten pregnant after marriage think that it is because they did not get enough rest during this period, or their nutrition was not adequate, etc., and they think that it has little to do with the small development of the follicles. In fact, the development of follicles directly affects pregnancy. So how to treat small follicles?

1. Anti-androgen

Since hyperandrogenism is the main underlying pathology of this disease, anti-androgen drugs should be used according to the source of androgens. For patients who need ovulation induction treatment, the hyperandrogenism condition should be corrected first, which can enhance the effect of ovulation induction medication.

(1) Cyproterone acetate (Dyne-35): Dyne-35 is a synthetic progestin with anti-androgen and anti-gonadotropin effects. It acts on androgen receptors and inhibits the secretion of LH and androgens. It reduces the effects of androgens by increasing the metabolic clearance rate of testosterone and the concentration of SHBG in the blood. It is effective for acne and hirsutism when used in combination with estrogen. It is the first choice for patients with hyperandrogenism, but it may aggravate hyperinsulinemia, so it should not be used for a long time.

(2) Oral contraceptives (OC): OC II contains more progestin than OC I and is often used to adjust the patient's cycle. It also has the effect of reducing androgen.

(3) Dexamethasone: It is the first choice drug for suppressing adrenal androgens. It is taken at a dose of 0.25 mg per day. It is usually discontinued after 3 to 6 months of use. It can suppress adrenal androgens to a low level.

(4) Spironolactone: Spironolactone is an antagonist of aldosterone and androgen receptors, used to reduce serum T and A levels. High-dose application can improve symptoms of hirsutism and is often used in combination with other drugs.

(5) Metformin: It reduces androgen levels by lowering INS levels and increasing INS sensitivity.

2. Treatment of insulin resistance IR and hyperinsulinemia

First, adopt a low-calorie diet and increase exercise. On this basis, use metformin, diazoxide and other drugs that reduce INS, which is beneficial to restore menstruation and ovulation.

3. Inhibit excessive endometrial hyperplasia

Some patients have endometrial hyperplasia, and they can use cyclical treatment with progesterone acetate, OCII, Marvelon, Xiyin, etc., and then start ovulation induction treatment after the condition is effectively controlled.

4. Ovulation induction therapy

Patients who are still unable to become pregnant after the above treatments need to receive ovulation induction treatment.

(1) Clomiphene (CC): CC is the patient's first choice for ovulation induction. Take 100 mg per day from the 5th to the 9th day of menstruation, and use HCG to induce ovulation when the follicles mature.

(2) HMG (FSH)/HCG: For patients who do not respond to CC, HMG (FSH) 75-150 IU/day can be directly applied after stopping CC or on the 5th day of menstruation, and HCG can be used to induce ovulation when the follicles mature.

As long as women find the corresponding treatment plan for their small follicle development, they will be cured. They can also adjust their menstrual cycle to allow the follicles to develop normally. A large part of the reason for the small development of follicles is due to endocrine disorders caused by obesity. Therefore, if you want to completely cure this disease, you must start with controlling your weight and try to keep your weight within the standard range.