How to identify borderline uterine fibroids

Uterine health issues are something that women need to pay special attention to in terms of care and health care. Once a bad disease is found in the uterus, it is not only a reproductive health issue for women, but will also affect their fertility. Therefore, every female friend must understand these diseases. The following will introduce the characteristics of borderline uterine fibroids. Female friends should pay attention to this common sense.

1 Cellular leiomyoma: The tumor cells are abundant but without cell atypia, and the nuclear division rate is 1 to 5/10HPF. It accounts for about 5% of fibroids. The texture of the tumor is relatively soft and slightly yellow; microscopically, the cells are obviously dense, with less cytoplasm and sometimes slightly irregular borders; it should be differentiated from stromal sarcoma, and clear diffuse myogenic expression in immunohistochemistry can assist in the diagnosis.

2 Diffuse leiomyomatosis is a rare benign tumor, the main clinical manifestation of which is vaginal bleeding. Morphologically, it is characterized by diffuse enlargement of the uterus and a large number of small leiomyoma nodules replacing the entire muscle wall. The boundaries of the nodules are unclear, and most are smaller than 1 cm, while the larger ones can reach 3 cm; the weight of the enlarged uterus can reach 1000 g. Microscopically, there are numerous fused, typical, cellular benign smooth muscle nodules, and sometimes perivascular smooth muscle hyperplasia is seen in the nodules or muscle layer.

3 Dissecting leiomyomas A small number of uterine leiomyomas appear malignant to the naked eye, but their histology and clinical course are benign. Because they are generally dissected and extend into the muscle layer, the tumor borders are irregular and the boundaries are unclear, they are also called "invasive leiomyoma". Microscopically, the tumor is well differentiated, highly edematous and degenerative, and extends into the surrounding muscle layer or broad ligament in a finger-like manner. The so-called "placental cotylenoid dissecting leiomyoma" (cotylenoid dissecting leiomyoma or "Sternberg tumor") is a subtype of dissecting leiomyoma, named because the congested exophytic tumor of the uterus extends into the broad ligament and pelvic cavity, and has a placenta-like appearance. Segmented leiomyoma can also present with various leiomyoma cell morphologies, such as rich cellularity and epithelioid. The diffuse desmin positivity of the former can be differentiated from stromal sarcoma, while those with epithelioid differentiation are classified as smooth muscle tumors of uncertain malignant potential. Similar growth patterns may be observed in edematous multinodular leiomyomata and the extravascular myoma component of intravenous leiomyomatosis.

As long as we understand the prevention and common sense of these diseases scientifically, we can better help ourselves in our daily lives, do a good job of health care, and effectively reduce the adverse effects and harms of this disease on the body. This is also a good way to ensure your own health and stay away from diseases.