Treatment of ovarian granulosa cell tumors

As the pace of life continues to accelerate, many office workers are always busy with work. However, since many women have poor stress resistance, some diseases always occur. In particular, the incidence of gynecological diseases continues to increase. Among them, ovarian granulosa cell tumor is a disease that troubles many women. Let us learn about the treatment of ovarian granulosa cell tumor.

Granulosa cell tumor of the ovary is the most common ovarian tumor with endocrine (estrogen-based) function. It can occur at any age, most of which occur after menopause and rarely during adolescence. There are often acute abdominal pain symptoms, which are prone to relapse in the late stage.

Patients with granulosa cell tumors have a 10 times higher chance of developing endometrial cancer than normal people. Granular cell tumors are also prone to be combined with uterine fibroids, which further aggravates the symptoms of irregular vaginal bleeding. 6% of patients may have breast cancer. When the tumor occurs in postmenopausal women, postmenopausal bleeding is a typical clinical symptom, and other manifestations may also occur, such as breast swelling, breast enlargement, and a right shift in the squamous epithelium maturation index of vaginal smears.

Treatment of ovarian granulosa cell tumors

1. Surgery

Surgery is the most important treatment for granulosa cell tumor, and the scope of surgery varies according to the clinical stage.

(1) Comprehensive staging surgery is performed for stage I, and intraoperative exploration is very important. The pelvis, abdominal organs, peritoneum, uterorectal fossa, etc. should be carefully examined, and biopsies should be taken from multiple locations.

(2) Patients at stage II and above should undergo cytoreductive surgery, including removal of the entire uterus, bilateral adnexa, greater omentum, para-aortic and retroperitoneal lymph nodes, and visible metastases.

(3) Surgical treatment of recurrent tumors: Patients with recurrent tumors should adopt a positive attitude and strive for another surgery, as surgery can improve the survival rate.

2. Chemotherapy

(1) Indications: ① Postoperative patients with stage I and II or above capsular rupture; ② Preoperative application for a small number of patients who are temporarily unable to undergo surgery due to other reasons.

(2) Drug selection and combination: No regimen as sensitive as the BEP regimen for treating malignant germ cell tumors of the ovary has yet to be screened out. Most of the chemotherapy regimens used should refer to those for malignant germ cell tumors or ovarian epithelial cancer.

3. Radiation therapy

Although granulosa cell tumor is not as sensitive to radiotherapy as dysgerminoma, it still has a certain therapeutic effect compared with other epithelial tumors. Currently, it is mainly used for comprehensive treatment of patients with advanced or recurrent disease

The above is an introduction to ovarian granulosa cell tumors. Gynecological diseases are particularly harmful to us. Sometimes in severe cases, they can lead to infertility. Therefore, female friends must maintain normal living habits and pay more attention to their own health issues. If abnormal leucorrhea and irregular menstruation occur, seek medical attention in time to avoid making the condition worse.