Reasons for poor doubling after transplantation

The fact that the blood volume HCG has doubled can be said to have touched the nerves of thousands of people. When taking a pregnancy test and waiting for the results, expectant fathers and mothers are like a group of students waiting to check their college entrance examination scores. All their previous efforts were just to get a satisfactory result, and the final result is just like this year's college entrance examination, with some happy and some sad.

So, if the blood HCG level does not double significantly after embryo transplantation, does it necessarily mean that the embryo has failed to implant?

In fact, for this question, you must first understand what blood HCG is!

Blood volume HCG, also known as human chorionic gonadotropin, is a glycoprotein metabolized by the trophoblast cells of the embryo and is composed of α and β dimers of glycoprotein. In the process of promoting pregnancy through in vitro fertilization, its main function is to confirm whether the woman is pregnant by testing the blood HCG test on the fourteenth day after the embryo transfer.

During the first 8-10 weeks of pregnancy, the HCG level in the blood will increase rapidly at a rate of about doubling every (2.2±0.5) days, and this process is called "HCG doubling in the blood."

In the eyes of many women, if the doubling of blood HCG is not effective or does not double, it means that the transplantation has failed. But in fact, the doubling of blood HCG is time-limited. It should be understood that for most women, the blood HCG value will begin to double within 48 hours after embryo transfer, and as the pregnancy progresses, the doubling time will also increase.

Under normal circumstances, when the blood level HCG is lower than 2000MIU/ml, the doubling time takes about 48 hours. When the blood level HCG reaches the range of 2000-6000MIU/ml, the doubling time takes about 72 hours. Once the blood level HCG exceeds 6000MIU/ml, the doubling time will directly increase to about 96 hours.

The so-called "if the blood volume HCG does not double significantly, it means that the fertilized egg has not implanted successfully" is actually not accurate.

Due to individual differences, everyone's blood HCG concentration is different, especially for pregnant women in the early stages of pregnancy, whose blood HCG levels are non-autonomous, so there will be certain fluctuations.

Under normal circumstances, if the blood HCG value is low, it may be an empty gestational sac, ectopic pregnancy or miscarriage, and when the blood HCG value is high, it may be a hydatidiform mole or multiple pregnancy.

It can be seen from this that after embryo transplantation, even if the short-term doubling of blood HCG does not achieve the ideal effect, don't make a judgment too early, which will only add trouble and negativity. This does not necessarily mean that your embryo implantation has failed. After all, the doubling still needs to be analyzed according to the specific situation and varies from person to person.