What causes bleeding after strenuous exercise?

If women bleed from their lower body after strenuous exercise, this may be a bleeding phenomenon caused by a disease. Usually, when the body has uterine disease or sex hormone disorders, it is easy to cause bleeding from the lower body. Timely treatment and care are needed. You need to pay more attention to your physical health and avoid too intense exercise.

What causes bleeding after strenuous exercise?

It is common in gynecological diseases such as vaginitis and cervicitis. The most common disease is functional uterine bleeding, and its pathogenesis is related to the following factors.

1. When there is an imbalance in sex hormone secretion and anovulatory functional uterine bleeding, the single and long-term estrogen stimulation causes the endometrium to proliferate progressively, proliferate to a highly adenocystic type, proliferate excessively into adenomatous type, and even gradually become endometrial cancer. Due to the lack of progesterone antagonism and glandular secretion, the endometrium is thickened, the glands increase, the glandular cavity is enlarged, and the glandular epithelium proliferates abnormally. The intimal blood supply increases and the spiral arterioles become tortuous. The polymerization and gelation of acidic particulate polysaccharide (AMPS) caused by estrogen reduces the permeability of blood vessels in the interstitium, affects the exchange of substances, causes local endometrial tissue ischemia, necrosis, and shedding, and causes bleeding. The coagulation effect of acidic particulate polysaccharide also hinders the shedding of the endometrium, causing asynchronous exfoliation of the endometrium and causing long-term irregular bleeding of the endometrium.

When there is ovulatory functional uterine bleeding, the corpus luteum may degenerate prematurely, resulting in a short luteal phase and frequent menstruation; or it may be incompletely atrophied and continuous secretion of progesterone, resulting in luteal phase (premenstrual) bleeding, prolonged menstruation, and continuous spotting, or both. The mechanism is insufficient secretion of estrogen and progesterone, especially insufficient secretion of progesterone, which causes the endometrium to be completely secreted, with immature development of glands, stroma and blood vessels, and due to the asynchronous withdrawal of estrogen and progesterone, irregular exfoliation of the endometrium and abnormal bleeding occur.

2. The role of prostaglandins: It is known that prostaglandins (PGs), especially PGE2, PGF2 thromboxane (TXA2) and prostacyclin (PGL2), are a group of highly active vascular and coagulation function regulatory factors. They affect endometrial bleeding function by regulating uterine blood flow, spiral arterioles and microcirculation, muscle contraction activity, endometrial lysosomal function and coagulation fibrinolytic activity.

TXA2 is produced in platelets, which causes microvascular constriction. Platelet aggregation, thrombosis, and hemostasis. PGL2 is produced in the blood vessel wall and has the opposite effect to TXA2, strongly dilating the microvessels, resisting platelet aggregation and preventing thrombosis. PGFa can cause constriction of endometrial spiral arteries, while PGE2 can dilate blood vessels. So TXA2 and PGL2, PGF2a. Disturbances in PGE2 function and dynamic balance can cause endometrial bleeding.

3. Abnormal structure and function of endometrial spiral arterioles and lysosomes. Abnormal spiral arterioles interfere with the microcirculation function of the endometrium, affect the shedding of the endometrial functional layer and the repair of blood vessels and epithelium on the detachment surface, affect vasoconstriction and local coagulation and fibrinolysis, and lead to abnormal uterine bleeding. From the follicular phase to the luteal phase, the number of lysosomes and the activity of their enzymes increase progressively. Progesterone stabilizes while estrogen destabilizes the lysosomal membrane. Therefore, when the estrogen/progesterone ratio is unbalanced before menstruation, the stability of the lysosomal membrane will be destroyed. The rupture of the lysosomal membrane will cause the precipitation and release of destructive hydrolases, which will cause endometrial cell rupture, endometrial layer collapse, necrosis and bleeding.