What are the symptoms of corpus luteum dysgenesis?

In medicine, the so-called corpus luteum generally refers to the corpus luteum of the female ovary, which is actually of great significance to the physical health of women. Clinically, some women are diagnosed with ovarian luteal insufficiency, which can cause harm to their bodies, such as infertility or menstrual disorders, and even if they become pregnant, they are prone to miscarriage. So, what are the symptoms of corpus luteum dysgenesis?

Symptoms of luteal insufficiency

1. Infertility: Because the corpus luteum cannot shrink and degenerate as scheduled or degenerates incompletely, the continuous secretion of a small amount of progesterone will cause the endometrium to be unable to shed at the normal time. The endometrium before menstruation still remains in the early secretion stage, making it difficult for women to conceive.

2. Menstrual disorders: Some patients with luteal insufficiency may experience menstrual disorders, such as shortened menstrual cycle, excessive or insufficient menstruation, prolonged menstruation, etc., which seriously endanger women's health.

3. Miscarriage: due to luteal insufficiency, the mother cannot secrete enough progesterone. Therefore, even if female patients with corpus luteum insufficiency conceive normally, it is difficult to maintain normal pregnancy, which may lead to miscarriage or habitual miscarriage.

Causes of luteal insufficiency

1. Defects in ovarian development and corpus luteum formation: The patient suffers from endocrine disorders that lead to follicle-stimulating hormone deficiency in the follicular phase, slow follicular development, and poor corpus luteum development. When the follicles mature, the ovulatory peak secretion of gonadotropin is insufficient, the function of promoting corpus luteum formation is weakened, and corpus luteum hypoplasia occurs.

2. Hyperprolactinemia: It inhibits the secretion of pituitary gonadotropin and can also directly act on the ovaries, causing follicular hypoplasia or corpus luteum hypoplasia.

3. Poor development of the follicle itself: defects in the number and functional differentiation of the granulosa cells of the follicle lead to poor luteinization of the granulosa cells and insufficient progesterone secretion after ovulation.

4. Endometriosis: The patient's peritoneal fluid increases significantly, affecting the maturation of follicles and leading to luteal insufficiency.

5. Others: Insufficient ovulation response induced by some drugs and excessive androgen levels can lead to luteal function defect.