What does HPV 33 positive mean?

Human papillomavirus infection can easily infect the human skin and mucosal squamous epithelium. The proliferative space-occupying lesions caused by HPV infection of the skin are called "warts", and the proliferative lesions caused by infection of the mucosal squamous epithelium are called "warts". HPV 33 positive may cause condyloma acuminatum and even cervical tissue cell diseases, including cervical papilloma and cervical cancer.

HPV33 refers to type 33 of human papillomavirus infection (HPV). HPV is a DNA tumor virus that mainly attacks human skin and mucous membranes, causing varying degrees of proliferative space-occupying lesions, including warts and fibrous papilloma, and some types can cause tissue lesions. HPV33 belongs to a subtype with a higher prevalence rate and is a high-risk HPV.

HPV33 definition

HPV33 refers to type 33 of human papillomavirus (HPV). HPV33 belongs to a subtype with a higher prevalence rate and is a high-risk HPV.

HPV33 composition

The HPV33 nucleocapsid has an icosahedral three-dimensional symmetrical structure, with 72 shell particles on the surface and no outer membrane. The diameter of the virus body is 45 to 55 nm. The viral genome is a 7.9 kb double-stranded circular DNA composed of three genetic gene regions, namely the early region (E), the late region (L) and unnumbered upstream and downstream adjustment regions. The E region numbering is related to viral replication, gene expression control and somatic cell transformation. The L region numbering is structural protein, including capsid protein L1 and capsid protein L2, which constitute the viral infectious capsid [1].

HPV33 Characteristics

HPV33 has host and tissue specificity and only infects human skin and mucosal squamous epithelial cells. Therefore, the only natural host of HPV is humans. The spread of HPV is mainly through direct contact with infected lesions or indirect contact with objects contaminated by the virus. Sexually transmitted infections are mainly spread through sexual contact, and newborn babies can be infected when passing through the birth canal. The virus infection only stays in parts of the skin and mucous membranes and does not cause viremia.

HPV33 infection symptoms

The symptoms of HPV33 and genital warts are similar. In the early stage of the disease, small, soft, light pink papules will appear on the affected area of ​​the patient, which will gradually increase and expand. Finally, as the condition worsens, they will combine to form growths of various shapes such as papilloma-like, cauliflower-like, and cockscomb-like. In addition, patients generally have no obvious active symptoms at the beginning. Sometimes some patients may show ulceration and secondary infection of the affected area, which may be accompanied by pain. When the warts grow into one, yellowish fluid will ooze out from the gaps between them.

HPV33 often appears with genital warts and cervical growth abnormalities. Warts can appear as small lumps or cauliflower-like growths. Warts can be seen in the private parts, the inner wall of the vagina, the inner and outer openings of the vagina, the anus or the cervix. Symptoms of HPV infection may also include vaginal burning, pain or bleeding during sexual intercourse. Some HPV infections are associated with cervical cancer, as well as tumors of the private parts and anus.

HPV33 testing method

The cytological examination method generally used internationally is the application of HPV-DNA gene testing technology, which can quickly make the early diagnosis and early detection of HPV33 virus infection a theory. In addition, this test method has high sensitivity and accuracy in identifying HPV virus infection, and the efficiency of the results obtained by conventional testing methods is much higher, and the false negative rate is greatly reduced, so it can be used to screen high-risk groups. If used effectively, more than 98% of patients with late-stage HPV infection can be detected.