How to do a biopsy of vulvar leukoplakia?

Some female friends will be nervous when they find white spots on their vulva, but if they are not sure what disease it is, they should get checked in time. Because some cancer lesions may also present with similar symptoms, careful examination is necessary for diagnosis.

1. For example, if the local mucosa of the vulva turns white, and there are phenomena such as itching, roughness, and desquamation, it will be diagnosed as vulvar leukoplakia. Of course, there are many types of vulvar leukoplakia. If the vulvar leukoplakia is of the hyperplastic type, that is to say, the local skin mucosa is thickened, the elasticity becomes worse, and corresponding ulcers and other discomfort symptoms also appear.

2. Cell biopsy: Sometimes the diagnosis of vulvar leukoplakia requires further cell biopsy to observe whether there are cancer cells in order to confirm the diagnosis. Biopsy pathological examination determines the nature of the lesion and excludes early cancer. Biopsy should be performed on chapped ulcers, protrusions, nodules or rough areas to ensure appropriate sampling. The diagnostic method for vulvar leukoplakia is to first apply 1% toluidine blue to the lesion area, and then use 1% acetic acid solution to scrub and decolorize it after the white is dry. Any area that does not discolor indicates the presence of naked nuclei, suggesting that there is a high possibility of finding atypical hyperplasia or even cancer during biopsy at this location. If the local damaged area is too large, treatment should be performed for several days until most of the lesions have healed, and then the biopsy site should be selected to improve the accuracy of diagnosis.

3. Pathological diagnosis basis: In addition to understanding the main clinical symptoms of the disease, we should also have a certain understanding of the pathogenesis of the disease, because there are many diseases that cause vulvar leukoplakia skin itching and hypopigmentation or decolorization, not just vulvar leukoplakia. Although their manifestations are somewhat different, it is not easy to distinguish them with the naked eye. Therefore, when encountering patients with atypical vulvar lesions or chronic chapped, localized thickening, ulceration and other symptoms, it is necessary to rely on biopsy pathological examination to confirm the diagnosis.