How to treat genital herpes? These methods should be kept in mind

If genital herpes occurs, patients must not be too afraid and should actively cooperate with the doctor for treatment. There are many treatment methods currently available, including drug therapy, local treatment, immunotherapy, etc.

1. Local therapy:

The principle is to dry, astringe, and protect the affected area to prevent secondary infection. You can apply 2% gentian violet solution, or 10% bismuth subgallate (dermatol), zinc oxide ointment or mud, lithospermum parkii ointment, 0.5% neomycin ointment, or 0.25%~0.1% IDU ointment, 5% IDU dimethyl sulfoxide solution (for skin herpes), etc. For the face, 10% aluminum acetate or zinc-copper mixture can also be used.

2. Systemic treatment:

The first principle of treatment is to make the infected HSV unable to activate or even eliminate the virus; the second is to regulate immunity and prevent recurrence. Acyclovir can be taken intravenously or orally, Livzonvir can be taken orally, interferon can be injected intramuscularly, and interleukin II can be injected intramuscularly. When we treat recurrent genital herpes, we use 3 million units of interferon produced by the Biotechnology Center of the Fourth Medical University for intramuscular injection, once a day, 10 times as a course of treatment, for a total of three courses, and appropriately use interleukin II, Levitra or Bactrobactin, and 95% of patients do not relapse.

3. Pathogen therapy

(1) Acyclovir (acyclovir): It can selectively inhibit viral replication, reduce the occurrence of new lesions, relieve pain, shorten wound healing and detoxification time. For primary or initial GH, 0.2g, orally, 5 times/d, for 7 to 10 days; for recurrent GH, 0.2g, orally, 5 times/d, for 5 days, or 0.4g, orally, 3 times/d, for 5 days, or 0.8g, orally, 2 times/d, for 5 days. For mild patients, 1 to 1.6g/d, divided into 5 times, for 5 to 7 days; for severe patients, 15mg/(kg·d), intravenous injection, for 5 to 7 days. Use with caution in patients with dehydration and renal insufficiency. In recent years, acyclovir (ACV) derivatives such as valacyclovir and famciclovir have also been used to treat this disease.

(2) Sodium foscarnet: For patients with TK gene defects who are resistant to ACV virus infection, 40 mg/kg of sodium foscarnet can be used by intravenous injection once every 8 hours until recovery.

(3) Ribavirin (ribavirin): 0.6-0.8 g/d, orally or intramuscularly, for 5-7 days.

(4) α, β and γ-interferon (α, β, γ-IFN): 1 million u/d for 5 to 7 days.

(5) 2-4 ml of poly I-2 is injected intramuscularly once every other day for 5-7 days.

(6) Cytarabine and other drugs can also be used.

4. Immunotherapy

Straus et al. used gD-2 vaccination, which is glycoprotein D of recombinant HSV-2 expressed in CHO cells, to induce antigen-specific neutralizing antibodies equivalent to or exceeding the level produced by GH patients. The vaccination was 100 μg/time, repeated once after 2 months. Compared with the control group, the number of relapses was significantly reduced, and it was also effective in alleviating symptoms and preventing infection.

5. Local therapy

Care should be taken to protect the wound surface, keep it clean and dry, and prevent secondary bacterial infection. 5% acyclovir (ACV) ointment or emulsion, α or β interferon emulsion or gel, 1% gentian violet solution, 3% tetracycline ointment or 25% zinc oxide oil can be used.

6. Symptomatic treatment

If secondary bacterial infection occurs, antibiotics should be used as appropriate, and analgesics can be given if the pain is severe.

7. Treatment of sexual partners

Because most sex partners are likely to be infected with HSV, they should also be tested and treated if necessary.

8. Traditional Chinese Medicine

(1) Damp-heat type:

Treatment method: Clear away heat and dampness, and detoxify.

Prescription: Longdan Xiegan Decoction plus or minus

(2) Liver and kidney deficiency type:

Treatment method: Clear away heat and dampness, nourish the liver and kidney.

Prescription: Zhibai Dihuang Pills combined with Bixie Shenshi Decoction with modifications.