Normal value of progesterone in the fifth week of pregnancy and its clinical application

We may not know much about the normal value of progesterone at five weeks of pregnancy. This is an indicator that reflects our normal body function. The normal value of progesterone at five weeks of pregnancy can reflect the changes in a certain aspect of our body in detail and objectively. By understanding the normal value of progesterone at five weeks of pregnancy, we can make timely and effective adjustments to our body and supplement the nutrients that the body is not lacking. If there is any disease, we should go to the hospital in time. So what is the normal value of progesterone at five weeks of pregnancy? And how can we balance the normal progesterone level at five weeks of pregnancy? Let us take a look at it together below.

Normal value:

Follicular phase: early 0.7±0.1ng/ml; late 0.4±0.1ng/ml

Ovulation period: 1.6±0.2ng/ml

Luteal phase: early 11.6±1.5ng/ml; mid-phase 22.5±1.5ng/ml; late 5.7±1.1ng/ml.

Clinical Application:

1. Monitor ovulation: blood progesterone level >15.6nmol/L indicates ovulation. If the progesterone level is consistent with ovulation and the patient has infertility without other reasons, B-type ultrasound examination is necessary to observe the follicular development and ovulation process to exclude luteinized unruptured follicle syndrome (LUFS). When using ovulation-inducing drugs, the blood progesterone level can be used to observe the ovulation-inducing effect. If multiple ovulation occurs and multiple corpora lutea are produced, the blood progesterone level may increase. Primary or secondary amenorrhea, anovulatory menstruation or anovulatory dysfunctional uterine bleeding, polycystic ovary syndrome, oral contraceptives or long-term use of GnRH agonists can all reduce progesterone levels.

2. Understand the function of the corpus luteum: If the blood progesterone level during the luteal phase is lower than the physiological value, it indicates insufficient corpus luteum function; if the blood progesterone level is still higher than the physiological level 4-5 days after menstruation, it indicates incomplete atrophy of the corpus luteum.

3. Understand the status of pregnancy: After ovulation, if the egg is fertilized, the corpus luteum continues to secrete progesterone. Starting from the 7th week of pregnancy, the placenta secretes progesterone in an amount that exceeds the corpus luteum of the ovary. When placental function declines during pregnancy, progesterone levels in the blood decrease. In case of ectopic pregnancy, the progesterone level is low. If the progesterone level is >78.0nmol/L (25ng/ml), ectopic pregnancy can be basically ruled out. If the single progesterone level is ≤15.6nmol/L (5ng/ml), it indicates a stillbirth. During threatened miscarriage, if the progesterone level shows a downward trend, miscarriage may occur. The amount of urinary pregnanediol excretion during pregnancy varies greatly among individuals, making it difficult to estimate placental function, so it is rarely used clinically.

4. Monitoring of progesterone replacement therapy: After removal of the luteal ovary in early pregnancy, plasma progesterone levels should be monitored when natural progesterone replacement therapy is used.

The above content introduces us to the normal value of progesterone at five weeks of pregnancy and how to balance the normal value of progesterone at five weeks of pregnancy. Through the above content, when we ourselves have the normal value of progesterone at five weeks of pregnancy, we can use the above method for treatment, which can avoid the difficulty of seeking medical treatment everywhere and restore health as soon as possible.