A man in Fuzhou often had stomach discomfort, and was shocked when he checked: he had 3 types of cancer at the same time! Be careful if you have black spots on these parts of your body →

There are one or two black spots on the body

It's not a rare thing.

It may be melanin nevus, pigmentation, etc.

But if you have black spots on your mouth,

Accompanied by gastrointestinal discomfort,

Then you must be especially vigilant!

A "black mole" on the mouth and polyps in the intestines revealed three types of cancer

Mr. Zhang (pseudonym), 78 years old, who lives in Fuzhou, has been suffering from gastrointestinal discomfort recently. Colonoscopy screening showed that there were a large number of polyps of varying sizes in his intestines , with more than 20 larger ones, and some polyps grew irregularly. The biopsy results suggested that Mr. Zhang actually suffered from three types of cancer - early descending colon cancer, sigmoid colon cancer and rectal cancer.

(Network image)

In addition, Mr. Zhang has an obvious facial abnormality - there are many black spots on his lower lip.

When asked by the doctor, Mr. Zhang said that he had these dark spots since he was a child, but he didn't pay much attention to them because they didn't affect his life.

Based on these symptoms, the team led by Chief Physician He Qingliang from the Department of Gastrointestinal Surgery, District 17, The First Affiliated Hospital of Fujian Medical University judged that Mr. Zhang was most likely suffering from PJ (Peutz-Jeghers) syndrome, also known as Peutz-Jeghers syndrome.

This is a relatively rare autosomal dominant genetic disease, which means that as long as one parent carries the disease-causing gene, the children have a 50% chance of inheriting the disease.

The incidence of this disease is low. Many consensus guidelines and clinical studies at home and abroad have pointed out that the prevalence of PJ syndrome is 1/200,000~1/8,000.

Chief Physician He Qingliang's team performed surgery on Mr. Zhang. Postoperative pathology and gene sequencing results also confirmed that Mr. Zhang was suffering from Peutz-Jeghers syndrome.
Fortunately, none of Mr. Zhang's children inherited the disease. After treatment, Mr. Zhang recovered and was discharged from the hospital soon.

Don't be too careful if you have these symptoms

Peutz-Jeghers syndrome is typically characterized by hyperpigmentation of the lips, palms, and soles and multiple gastrointestinal polyps .

Pigmented spots: usually appear in childhood and range in color from dark brown to black;

Polyps: They can be distributed throughout the digestive tract, with the most concentrated distribution in the small intestine. The pathological type is mainly hamartoma polyps. Polyps may cause secondary bleeding, obstruction, intussusception, perforation, malignant transformation, etc.

In addition, patients with Peutz-Jeghers syndrome have a susceptibility to tumors, and have a higher risk of both digestive system and non-digestive system tumors.
If a patient has the above-mentioned typical symptoms of lip pigmentation and gastrointestinal polyps and has family members suffering from the disease, the disease should be highly suspected.

Confirmation of the disease usually requires genetic testing to identify mutations in the STK11 gene.

Patients diagnosed with the disease should pay attention to:

1. Maintain healthy eating habits, avoid spicy and irritating foods , and increase fiber intake to help intestinal health, reduce intestinal inflammation, and subsequently reduce the rate of polyp canceration.

2. Perform regular endoscopic examinations (gastroscopy, small intestinal capsule endoscopy or colonoscopy) to monitor changes in polyps and detect and treat any abnormalities in a timely manner.