[Medical Q&A] Does estrogen and progesterone supplementation really increase the risk of breast cancer?

Planner: Chinese Medical Association

Reviewer: Kong Xiangyi, deputy chief physician, Cancer Hospital, Chinese Academy of Medical Sciences

Perimenopausal women often face the problem of decreased estrogen levels. Estrogen supplementation can alleviate the symptoms of perimenopausal syndrome. There are two main methods: estrogen-progestin combined therapy and estrogen monotherapy. The relationship between these two methods and breast cancer risk depends on the state of the uterus.

1. Women with an intact uterus: Combined estrogen-progestin therapy may increase the risk of breast cancer.

2. Women who have had their uterus removed: Using estrogen alone may reduce the risk of breast cancer. The specific mechanism of this phenomenon is not yet fully understood, and scientists are conducting in-depth research on its molecular biological basis.

Therefore, when choosing hormone replacement therapy, perimenopausal women should consider their uterine condition and communicate fully with their doctors to assess the risks and benefits of treatment. Knowing this information can help women make more informed health choices.