Do you know about Parkinson's disease medication? | Science Time

Parkinson's disease is a chronic neurodegenerative disease that mainly affects the motor ability of middle-aged and elderly people, causing symptoms such as muscle stiffness, tremors and bradykinesia. Dopamine drugs: Dopamine drugs are the most basic and effective drugs for the treatment of Parkinson's disease. Dopamine is a neurotransmitter that participates in the transmission of nerve signals in the human body and plays a key role in controlling muscle movement and coordination.

1. Precautions for use

Follow the doctor's instructions: Patients should take the medicine strictly according to the doctor's instructions and should not increase or decrease the dosage or change the way of taking the medicine on their own. If you have any questions or discomfort, you should consult a doctor in time.

Regular and quantitative administration: Try to take the medicine at a fixed time every day to ensure a stable concentration of the medicine in the body. Avoid missing or taking the wrong medicine, which may affect the treatment effect or cause adverse reactions.

Avoid interference from food or drinks: Certain foods or drinks may interact with drugs, affecting the absorption and effect of the drugs. Patients should avoid taking stimulating drinks such as coffee, tea, and juice, as well as foods high in fat, sugar, and salt, at the same time as the drugs. In addition, some drugs need to be taken on an empty stomach or after meals, so patients should pay attention to the doctor's instructions.

Monitor physical reactions: During medication, patients should pay attention to their physical reactions. If abnormal symptoms such as dizziness, fatigue, muscle pain, etc. occur, they should inform the doctor in time. At the same time, pay attention to changes in the condition so as to adjust the treatment plan in time.

Avoid sudden medication discontinuation: Parkinson's disease treatment requires long-term medication. Patients should not suddenly discontinue medication or change their treatment plans on their own. Sudden medication discontinuation may lead to worsening symptoms, withdrawal syndrome and other adverse reactions, affecting the effectiveness of treatment.

Pay attention to drug storage: Some drugs need to be stored under specific conditions, such as refrigeration or protection from light. Patients should pay attention to the storage requirements of drugs to ensure the quality of the drugs.

II. Effects and adverse reactions of some drugs

Madopar: Its main function is to supplement the deficiency of dopamine in the brain, thereby improving the movement disorder symptoms of Parkinson's patients. Madopar can relieve symptoms such as muscle rigidity, tremor and bradykinesia, and improve patients' daily living ability. Common adverse reactions include gastrointestinal symptoms such as nausea, vomiting, diarrhea, and cardiovascular symptoms such as palpitations and chest tightness. A small number of patients may experience serious adverse reactions such as orthostatic hypotension and arrhythmia. Long-term use of Madopar may also lead to special adverse reactions such as dyskinesia and on-off phenomenon.

Sinemet: used to treat the symptoms and signs of Parkinson's disease, such as muscle rigidity and bradykinesia. Sinemet can inhibit the metabolism of levodopa and increase its concentration in the brain, thereby enhancing the therapeutic effect of levodopa. Common adverse reactions include digestive symptoms such as nausea, vomiting, diarrhea, and psychiatric symptoms such as insomnia and hallucinations. A small number of patients may experience serious adverse reactions such as orthostatic hypotension and arrhythmia.

Selegiline: A monoamine oxidase B inhibitor that improves the symptoms of Parkinson's disease patients by inhibiting the degradation of neurotransmitters and prolonging their action time in the synaptic cleft. Selegiline can reduce the degradation of dopamine and help maintain the level of dopamine in the brain. Common adverse reactions include dry mouth, constipation, insomnia, etc. A small number of patients may experience mental symptoms such as mood swings and delusions.

Kedan: It can reduce the metabolism of levodopa and increase its concentration in the brain, thereby enhancing the therapeutic effect of levodopa. There are few adverse reactions, including nausea, vomiting, diarrhea and other gastrointestinal symptoms. Long-term use of Kedan may cause adverse reactions such as involuntary movements and chorea.

Rasagiline: A selective monoamine oxidase A inhibitor that helps maintain dopamine levels in the brain, thereby improving symptoms in patients with Parkinson's disease. Rasagiline prevents the degradation of dopamine and increases its concentration in the brain. Common adverse reactions include cough, rhinitis-like symptoms, headache, etc. A small number of patients may experience gastrointestinal discomfort, insomnia and other adverse reactions.

Dopamine: a dopamine receptor agonist that promotes the release and transport of dopamine and relieves movement disorders in Parkinson's syndrome, such as muscle stiffness and bradykinesia. Dopamine can improve patients' muscle stiffness and bradykinesia and improve their ability to live a normal life. Common adverse reactions include gastrointestinal symptoms such as nausea, vomiting, and diarrhea, as well as cardiovascular symptoms such as palpitations and chest tightness.

Lidocaine: An anticholinergic drug that can reduce some symptoms of Parkinson's disease, such as tremors and muscle stiffness, while also increasing heart rate and blood pressure and improving a patient's ability to move. Lidocaine blocks the effects of acetylcholine, thereby reducing symptoms such as tremors.

Finally, it is important to remind you that Parkinson's disease is a chronic disease that requires long-term treatment and management. Patients should establish a long-term partnership with their doctors, develop a suitable treatment plan, and remain patient and actively cooperate during the treatment process to achieve the best treatment results.

Author: Pan Xueying Wuming Hospital Affiliated to Guangxi Medical University