Women's menstrual period is cyclical, generally occurring once a month. For this reason, menstrual period can also be called menstruation. If a woman is under great work pressure, is in a bad mood, or has been overeating for a period of time, then her period is likely to come early or late. Of course, not all delayed menstruation is caused by illness. A delay of one or two days is normal. But some women find that their urine is pink when they are not having their period. Why is that? If you have had regular menstruation in the past, but your menstruation is delayed this time, you should first determine whether you are pregnant. It is recommended to have a blood test for hcg. Human chorionic gonadotropin is a glycoprotein secreted by trophoblast cells of the placenta and is composed of α and β dimers. Human chorionic gonadotropin (HCG) αβ is synthesized by syncytial trophoblasts. A glycoprotein hormone with a molecular weight of 36,700. The α subunit is basically similar to FSH (follicle stimulating hormone), LH (luteinizing hormone) and TSH (thyroid stimulating hormone) secreted by the pituitary gland, so they can cross-react with each other, while the structures of the β subunits are different. β-HCG is similar to β-LH in structure, but the last 24 amino acids are not present in β-LH. Function: (1) It has the functions of FSH and LH, maintaining the life of the menstrual corpus luteum and making it enlarge into the corpus luteum of pregnancy; (2) Promote the aromatization of androgens into estrogens and stimulate the formation of progesterone; (3) Inhibit the stimulation of lymphocytes by plant lectins. Human chorionic gonadotropin can be adsorbed on the surface of trophoblast cells to prevent embryonic trophoblast cells from being attacked by maternal lymphocytes. (4) LH-like function: before the fetal pituitary gland secretes LH, it stimulates the fetal testicles to secrete testosterone to promote male sexual differentiation; it can also promote gonadal development, and in men, it can stimulate the activity of interstitial cells in the testicles and increase the secretion of androgen (testosterone). It is of great significance for the treatment of male patients with combined pituitary deficiency. It can not only promote gonadal development and the secretion of male hormones, but also promote the development of secondary sexual characteristics. (5) Can bind to the TSH receptors of maternal thyroid cells and stimulate thyroid activity. Human chorionic gonadotropin enters the maternal blood after fertilization and proliferates rapidly until the 8th week of pregnancy, then slowly decreases in concentration until the 18th to 20th week, and then remains stable. Generally, an increase in the level of human chorionic gonadotropin to at least 2.5MoM is associated with Down syndrome. However, the actual average level of complete human chorionic gonadotropin in the maternal blood of DS patients is only 1.3MoM, which cannot clearly identify DS patients. The human chorionic gonadotropin-related molecules used for DS examination are free b-hCG and high sugar hCG (H-hCG). |
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