Genital warts squeeze out small white rice grains

There are many symptoms of genital warts, some are cockscomb-shaped and some are small red rashes. Genital warts can make people feel very itchy, but you should not scratch them with your hands, because if they rupture, they will cause the warts to spread. Some people have found that they can squeeze out some small white particles with their hands from the places where genital warts grow. Let’s take a look at how small white rice grains are squeezed out from genital warts.

Genital warts are a sexually transmitted disease caused by human papillomavirus (HPV) infection, with proliferative lesions in the anal and genital area as the main manifestation. Most cases occur in young and middle-aged people aged 18 to 50. The disease occurs after an incubation period of about half a month to eight months, with an average of three months. This disease is relatively common and is mainly transmitted through sexual contact.

The incubation period is 1 to 8 months, with an average of 3 months, and it mainly occurs in sexually active people.

1. Typical genital warts

The genitals and perianal area are the most common sites. In men, it is more common in the foreskin, frenulum, coronal sulcus, glans penis, urethral orifice, penis shaft, perianal area, rectum and scrotum. In women, it is more common in the labia majora and minora, posterior symphysis, vestibule, clitoris, cervix and perianal area. It can occasionally be seen in areas other than the genitals and perianal area, such as the armpits, umbilicus, mouth, breasts, and between the toes. Female vaginitis and male foreskin are factors that promote the occurrence of genital warts.

The lesions initially appear as small, light red papules, which gradually increase in size and number, and are distributed singly or in clusters. They are moist and soft, with an uneven surface and appear as nipple-like, cockscomb-like, or cauliflower-like protrusions. Red or dirty grey. The roots often have pedicles and are prone to erosion and exudation, and bleed easily when touched. Purulent secretions often accumulate between the cracks of the skin lesions, causing a foul odor, and secondary infection may occur due to scratching. This disease often has no subjective symptoms, and some patients may experience foreign body sensation, pain, itching or pain during sexual intercourse. Genital warts in the rectum may cause pain, blood in the stool, and a feeling of tenesmus.

2. HPV subclinical infection

HPV infection cannot be identified clinically by the naked eye, but evidence of HPV infection can be found by acetic acid whitening test (local whitening after applying or compressing with 5% acetic acid solution), tissue pathology or nucleic acid detection technology.

3. Relationship with tumors

A large amount of epidemiological data shows that HPV infection (mainly high-risk HPV, such as HPV-16 and HPV-18) is closely related to the occurrence of genital cancers, such as cervical cancer and penile cancer.

The prognosis is generally good after treatment. However, no matter which treatment method is used, recurrence is possible.

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1. Acetic acid whitening test

Topical application or wet compress of 3% to 5% acetic acid solution for 5 to 10 minutes can cause whitening in the HPV-infected area, the so-called "acetic acid whitening phenomenon." However, the specificity is not high, and some chronic inflammations, such as candidal vulvitis, genital trauma and nonspecific inflammation, may result in false positives.

2. Cytological examination

Using vaginal or cervical wart tissue smears and Papanicolaou staining, two types of cells can be seen, namely vacuolated cells and dyskeratotic cells, which are of diagnostic value for condyloma acuminatum.

3. Histopathological examination

The presence of vacuolated cells above the spinous layer and in the granular layer is important evidence for diagnosing HPV infection.

4. Immunological tests

Antibodies against HPV proteins are used to detect HPV antigens in lesions. The sensitivity of this method is not high, with a detection rate of only about 50%.

5. Nucleic acid hybridization test

It is an important means of detecting HPV infection, including dot blot hybridization, tissue in situ hybridization, and nucleic acid imprinting (Southern blot hybridization). These methods have high specificity and sensitivity and are sensitive and reliable methods for diagnosing HPV infection. However, the technical operation is cumbersome and has not been widely used in clinical practice.

6. Polymerase chain reaction (PCR)

It is currently the most sensitive method for detecting HPV infection, and can also perform type-specific analysis. It has the characteristics of high sensitivity, simplicity and rapidity. It has been widely used clinically.