What are the consequences of excessive thickness of the menopausal endometrium?

As they age, women will enter menopause and then slowly stop menstruating. After this period, many women will experience other abnormal conditions. Many women are troubled by the thickness of their endometrium. I believe everyone wants to live a healthy life, but what consequences will result from excessive thickness of the menopausal endometrium? Let’s see what it says below!

A meta-analysis of studies found that the incidence of endometrial cancer in postmenopausal women without vaginal bleeding was less than 0.25%, regardless of endometrial thickness [5]. In a prospective study in 2000, hysteroscopy was performed on women with endometrial thickness ≤ 4 mm and who had been postmenopausal for more than one year. The results showed that one case of adenocarcinoma was found in 199 asymptomatic women, with a malignant transformation rate of 0.5%[6]. This number is similar to other retrospective or observational studies.

In another prospective study in 2009, the authors defined endometrial thickening as endometrial thickness ≥6 mm and found a total of 3 cases of atypical hyperplasia (1%) and 12 cases of endometrial adenocarcinoma (3%) in a total of 304 patients (mean age 64.8 years, mean endometrial thickness 12 mm) [7]. In this study, the cancer incidence rates for endometrial thicknesses of 6-10 mm, 11-15 mm, 16-20 mm, and > 20 mm were 3% (4/127), 2% (2/98), 5% (2/43), and 11% (4/36), respectively. All three cases of dysplasia occurred in patients with intimal thickness > 15 mm (4%). This result is confusing because, except for cases where the endometrial thickness exceeds 20 mm, the incidence of malignancy in patients with other different endometrial thicknesses is similar and particularly high, which is similar to that of postmenopausal vaginal bleeding. The selection bias of this study is noteworthy, as the overall age was older, and more than 65% of the patients had at least one high-risk factor for endometrial cancer (BMI > 30, obesity, or diabetes).

After reading the above introduction, I believe you already know what consequences will be caused by excessive thickness of the menopausal endometrium! Excessive thickness of the endometrium can cause many diseases, so when women find that their endometrium is too thick, they must go to the hospital for examination and treatment in time. I hope that all patients can recover soon!