What is the value of human chorionic gonadotropin?

When you hear the term "human chorionic gonadotropin value", you may be confused. You have never heard of this term before. This is normal as it is an uncommon word. However, what is certain is that this is a term related to human hormones. It is recommended that everyone learn more about this common sense, which will be beneficial to everyone's health. I hope that everyone can gain something from my explanation.

Human chorionic gonadotropin is a glycoprotein secreted by trophoblast cells of the placenta and is composed of α and β dimers. Human chorionic gonadotropin (HCG) αβ is synthesized by syncytial trophoblasts. A glycoprotein hormone with a molecular weight of 36,700. The α subunit is basically similar to FSH (follicle stimulating hormone), LH (luteinizing hormone) and TSH (thyroid stimulating hormone) secreted by the pituitary gland, so they can cross-react with each other, while the structures of the β subunits are different. β-HCG is similar in structure to β-LH, but the last 24 amino acids are not present in β-LH.

Function

(1) It has the functions of FSH and LH, maintaining the life of the menstrual corpus luteum and making it enlarge into the corpus luteum of pregnancy;

(2) Promote the aromatization of androgens into estrogens and stimulate the formation of progesterone;

(3) Inhibit the stimulation of lymphocytes by plant lectins. Human chorionic gonadotropin can be adsorbed on the surface of trophoblast cells to prevent embryonic trophoblast cells from being attacked by maternal lymphocytes;

(4) LH-like function: before the fetal pituitary gland secretes LH, it stimulates the fetal testicles to secrete testosterone to promote male sexual differentiation; it can also promote gonadal development, and in men, it can stimulate the activity of interstitial cells in the testicles and increase the secretion of androgen (testosterone). It is of great significance for the treatment of male patients with combined pituitary deficiency. It can not only promote gonadal development and the secretion of male hormones, but also promote the development of secondary sexual characteristics.

(5) Can bind to the TSH receptors of maternal thyroid cells and stimulate thyroid activity.

Complete human chorionic gonadotropin is produced entirely by the syncytiotrophoblast of the placental chorion. Its main function is to stimulate the corpus luteum, which is beneficial to the continuous secretion of estrogen and progesterone, so as to promote the formation of uterine decidua and make the placenta grow and mature. It is now believed that human chorionic gonadotropin is produced by trophoblast transitional cells and syncytial cells. Human chorionic gonadotropin begins to be secreted 10-14 days after conception and reaches its peak 60-70 days later. It increases rapidly during the first 8 weeks of pregnancy to maintain the pregnancy. After about 8 weeks of pregnancy, human chorionic gonadotropin gradually decreases until it reaches relative stability at about 20 weeks.

The absolute values ​​of serum human chorionic gonadotropin vary greatly when compared between different periods of pregnancy and between pregnant women. Since each person is different, there is no comparability and they can only be compared within themselves. Generally non-pregnant women: blood HCG <100IU/L

During the first 3 months of pregnancy, HCG levels approximately double every 2.2±0.5 days.

Urine-HCG (HCG semi-quantitative method):

Non-pregnant women <25 IU/L,

40 days of pregnancy>5000IU/L,

60-70 days of pregnancy>(8-32)×104IU/L (the human chorionic gonadotropin level in urine is highest in the early morning and is close to the serum level).

Serum HCG levels during normal pregnancy:

HCG (IU/L) in weeks of pregnancy

0.2-1 week 5-50

1-2 weeks 50-500

2-3 weeks 100-5000

3-4 weeks 500-10000

4-5 weeks 1000-50000

5-6 weeks 10,000-100,000

6-8 weeks 15,000-200,000

February-March 10,000-100,000

This is all the common knowledge about chorionic gonadotropin values ​​that we have introduced to you. I hope the above article can help you understand chorionic gonadotropin values ​​more deeply. Women who are already pregnant must go to the hospital regularly to check and measure their blood pressure. If any abnormalities are found, they should immediately seek medical treatment until the values ​​return to normal.