The significance of the four blood coagulation tests in pregnant women

Childbirth is a normal physiological phenomenon in pregnancy. Currently, childbirth can be natural or surgical, that is, normal delivery and cesarean section. At this time, it is necessary to do four coagulation tests for pregnant women. This is a must-do examination for pregnant women. We must first understand the significance of the four coagulation tests for pregnant women so that pregnant women know why they need to do this examination, so as to avoid patients raising questions during the examination, which will cause distrust of the hospital.

Under normal conditions, the body's coagulation system and anticoagulation system are in a dynamic balance. The interaction and mutual restraint of substances that promote and inhibit coagulation constitute the self-regulation of the coagulation mechanism. The body of a pregnant woman in labor is in a hypercoagulable state, with enhanced coagulation function and weakened anticoagulant and fibrinolytic functions. This state is conducive to rapid and effective hemostasis, but at the same time it is also prone to thrombosis and obstetric complications. Therefore, testing the four coagulation indexes before delivery is extremely important for preventing obstetric complications and ensuring the safety of mother and child.

Pregnancy is a special physiological process, during which various indicators of the body will change. The blood of pregnant women about to give birth is in a hypercoagulable state, and the four coagulation indicators will also undergo a series of physiological changes. Especially in the late pregnancy, various coagulation factors of pregnant women increase to varying degrees, especially the fibrin content increases significantly. PT mainly reflects the levels of exogenous coagulation factors I, II, V, VII, and X in plasma. It is a relatively sensitive and commonly used screening test for the extrinsic coagulation system. APTT mainly reflects the levels of endogenous coagulation factors VIII, IX, XI, and XII. It is a relatively sensitive and commonly used screening test for the intrinsic coagulation system. TT is an experiment that reflects the common coagulation pathway and can also reflect the quality and quantity of FiB in the blood. The increase in coagulation factor concentration during pregnancy ultimately leads to shortened PT, APTT, and TT times in the plasma of pregnant women, and increased FIB, which can enhance cell and platelet aggregation, increase blood viscosity, and enhance hemostasis. But it is also prone to cause thrombosis.

The tendency of pregnant women in labor to be in a hypercoagulable state provides a material basis for rapid and effective hemostasis after delivery, but it also increases the risk of accidents. Therefore, timely monitoring of the four coagulation indicators before delivery is of great significance for clinical selection of appropriate delivery methods, prevention and treatment of abnormal maternal bleeding, and protection of maternal and child safety. Therefore, failure to check the four coagulation tests during pregnancy will affect normal delivery. Clinically, pregnant women must undergo the four coagulation tests during pregnancy.

The four coagulation tests for pregnant women mainly include prothrombin time, activated partial thromboplastin time, thrombin time, and fibrinogen. The purpose of the examination is to detect blood abnormalities and prevent patients from having hemostatic dysfunction, which will cause uncontrollable bleeding during delivery. When patients understand the significance of the four coagulation tests for pregnant women to delivery, they must do this examination when they are about to give birth, especially pregnant women undergoing caesarean section should pay more attention.