Introduction to complex endometrial hyperplasia

In order to prevent the occurrence of complex endometrial hyperplasia in life, we need to have a certain understanding of its causes. The cause of complex endometrial hyperplasia is generally due to the fact that female friends do not develop good living habits and pay attention to the cleanliness of the area around the uterus. Therefore, it is recommended that female friends can read the article introducing complex endometrial hyperplasia.

Endometrial hyperplasia refers to a group of proliferative lesions occurring in the endometrium, only a few of which can slowly develop into cancer. The cause of endometrial hyperplasia is mainly related to long-term estrogen stimulation. For example, due to the absence of ovulation, the endometrium is in a state of hyperplasia for a long time and lacks periodic secretory phase transformation; the body is stimulated by high levels of estrogen, either endogenously (such as endocrine functional tumors in the ovaries or pituitary glands) or exogenously (such as estrogen replacement therapy).

Clinically suspicious cases should undergo endometrial curettage for histological diagnosis. Endometrial hyperplasia is histologically classified into simple hyperplasia, complex hyperplasia, and atypical hyperplasia. Atypical endometrial hyperplasia refers to a proliferative lesion in which cells have morphological characteristics of atypical changes. It is divided into three degrees: mild, moderate and severe according to the severity of the lesion. Both simple hyperplasia and complex hyperplasia have no cellular atypia, but the degree of changes in glandular structure is different. Simple hyperplasia is considered to be a physiological response of the endometrium to the body's high estrogen state. The most common cause is anovulatory menstruation, which often occurs in women before menarche or menopause. If ovulation occurs or progesterone is used, the lesions may regress and return to normal and generally do not develop into cancer.

A small number of complex hyperplasias may develop into atypical hyperplasia, thus affecting the prognosis. The canceration rate of atypical hyperplasia is 23%, among which the canceration rate of severe atypical hyperplasia can reach 30%~50%, so it is listed as a precancerous lesion. In cases of mild or moderate atypical hyperplasia, the response to drug treatment is good and rapid. After persistent treatment, some cases can still conceive and complete childbirth. After drug treatment, patients with endometrial hyperplasia have milder endometrial lesions or return to normal, and can even become pregnant, but there is still a possibility of recurrence after stopping the drug or after delivery.

This tendency to relapse may be related to the failure to fundamentally correct the factors that cause high estrogen levels in the human body. In short, most patients with endometrial hyperplasia have a good prognosis after active drug treatment. Patients with moderate to severe atypical hyperplasia should be closely followed up during treatment. If a few patients are found to have poor treatment efficacy, hysterectomy can be performed in time to avoid development of cancer.

The above introduces us to the disease of complex endometrial hyperplasia in detail. I hope that after reading it, you will have a certain understanding of this disease. Generally, when we encounter complex endometrial hyperplasia in life, we should go to the hospital for examination in time and choose the method of treating endometrial hyperplasia according to the doctor's advice.