Causes of granulomatous mastitis

Everyone must know the importance of breasts to female friends. Female friends must protect their breasts because breasts are prone to various diseases. Female friends can learn more about common breast diseases so that they will know how to deal with them once there are problems with their breasts. So how should female friends treat granulomatous mastitis? Let us first understand the cause of granulomatous mastitis.

Granulomatous mastitis is a type of chronic breast inflammation with granuloma as the main pathological feature. It includes multiple clinical diseases, one of which is more common and has unknown cause. Granulomatous inflammation is centered on the mammary lobules, so it is called granulomatous lobular mastitis (GLM). It was first reported by Kessler in 1972, and the name of the disease has been recognized by most scholars. In the past, some people called it idiopathic granulomatous mastitis, breast granuloma or granulomatous lobularitis. It refers to granulomatous lesions of the breast with non-caseous necrosis limited to the lobules. No pathogen can be found. It may be an autoimmune disease. Like granulomatous thyroiditis and granulomatous orchitis, it is easily confused with tuberculous mastitis. The incidence rate was not high in the past, so clinical and pathological doctors did not observe and study it much.

1. Autoimmune diseases: local immune phenomena and local hypersensitivity reactions caused by breast milk. Non-bacterial infection associated with the use of oral contraceptives. It may also be related to infection, trauma, and chemical stimulation that causes inflammation, destroys the ductal epithelium, and allows the contents of the cavity to enter the lobular interstitium, causing granulomatous reactions and further destroying the lobular structure. It is common in married and multiparous women of childbearing age.

2. It may be due to the reverse escape of milk, secretions and keratinized epithelium in the duct into the lobular interstitium, causing local inflammatory and hypersensitivity reactions, leading to the formation of granulation tissue.

3. Microabscesses, epithelial macrophages and foreign body granulomas can be seen in the lesions. It is believed that the disease is caused by local infection, trauma and inflammation caused by chemical substances. The ductal epithelium is destroyed due to inflammatory damage, and the contents of the ductal cavity enter the lobular interstitium, causing granulomatous inflammation.

In the above article, we introduced the importance of breasts to female friends. Female friends must protect their breasts. The above article introduced what granulomatous mastitis is and the cause of granulomatous mastitis.