46 days of pregnancy with gestational sac but no embryo

What causes the termination of growth and development of test tube embryos? In vitro fertilization termination refers to the termination of embryo development in early pregnancy due to some reasons, which clinically falls into the category of miscarriage or stillbirth. There are many reasons for fetal growth retardation, such as: uterine problems, reproductive immunity problems, blood collection problems of the pregnant mother, reproductive endocrine problems, etc.

46 days of pregnancy with gestational sac but no embryo

If there is a gestational sac but no fetal bud or fetal heartbeat at 46 days of pregnancy, it is possible that the test tube embryo has terminated its development. If there are symptoms such as abdominal pain and vaginal bleeding, you can first receive tocolysis treatment.

In addition, dynamically check the changes in the blood chorionic gonadotropin level and the level of progesterone. If the increase in the blood chorionic gonadotropin level during the observation process is relatively small or there is a downward trend, and the progesterone level is very low, it may be considered that the test tube embryo has terminated development.

Then, follow up with B-ultrasound 5-7 days later to check the status of the test tube embryo in the uterine cavity. If there is still no embryo bud or fetal heartbeat, it means that the test tube embryo has stopped growing and developing, and it is recommended to terminate the pregnancy immediately.

What causes the termination of growth and development of test tube embryos?

If the embryo stops developing, all pregnancy reactions of the pregnant mother will gradually disappear. First of all, you will no longer have nausea, vomiting and other early pregnancy reactions, and the feeling of breast swelling will also gradually weaken. This is followed by vaginal bleeding, often with dark red, bloody leucorrhea. Eventually, you may experience lower abdominal distension and pain, and the test tube embryo may be expelled. The above symptoms vary from person to person. Some people may not even have any symptoms, but may experience abdominal pain immediately, followed by miscarriage, or the embryo may stop developing and then be discovered through basic B-ultrasound examination without any symptoms.

Fetal growth retardation refers to the cessation of growth and development of the embryo in early pregnancy due to some reasons. B-ultrasound examination showed that the fetal heart or fetal shape was irregular in the gestational sac, there was no fetal heartbeat, or the gestational sac was withered. Clinical medicine classifies it as miscarriage or fetal death. There are many reasons for fetal growth retardation. There are five common reasons:

1. Reproductive endocrine problems. The initial growth and development of test tube embryos requires three key growth hormones (estrogen, estrogen, and chorionic gonadotropin). If the pregnant mother's own endogenous growth hormone is insufficient, it will lead to the arrest of test tube embryos. It is the most important part of traditional tocolysis.

2. Problems with the uterus, mainly the extracellular fluid of the uterus, uterine septum and other problems, can be solved by BC and hysteroscopy.

3. For problems with sex chromosomes, the couple can have their blood drawn for a checkup, which can be easily eliminated.

4. The problem of reproductive immunity is divided into autoimmune type and homoimmune type. The examination is relatively complicated and most doctors do not understand it.

5. The pregnant mother has blood collection problems and high coagulation function, which may cause venous thrombosis and affect the blood flow in the uterine artery. This may cause insufficient blood supply to the embryo and may also cause problems for the baby.

Possible problems of fetal malformation during early pregnancy and ways to prevent it

1. Intense pregnancy: Ketosis can cause abnormal development of the baby, because the nutritional imbalance caused by pregnancy can also affect the normal growth and development of the fetus.

Hyperemesis gravidarum is a physiological phenomenon. If it does not develop into a pathological condition, pregnant women with decreased appetite can eat small meals frequently, eliminate psychological worries, treat reactions correctly, and pay attention to maintaining a balanced diet to successfully pass the reaction period. If pregnancy vomiting does not respond well to active treatment and lasts for a long time, longer than a long period of time during early pregnancy, you should carefully check whether the baby has any abnormalities in development.

2. Fever: Fever during early pregnancy can cause fetal malformation. Although no major structural malformations will occur after the fetal period, it can damage the baby's brain and cause muscle spasms and intellectual disabilities in the baby after birth. In addition to preventing illness and fever during pregnancy, other factors that can cause the body temperature of pregnant women should also be prevented. There are reports of increased incidence of developmental malformations in positions such as outdoor work and daily activities such as hot tubs and saunas. In addition to fetal malformations, the rates of miscarriage and fetal stillbirth may also increase.

3. Intrauterine infection: The most common intrauterine infections during early pregnancy are Toxoplasma, rubella virus, mumps virus, varicella, etc. These viral infections or Plasmodium infections can cause fetal malformations or illness and disability. Vaccination should be vigorously carried out to avoid their occurrence as much as possible.

4. Threatened abortion: In case of threatened abortion, the first thing to do is to eliminate the possible maternal factors such as uterine fibroids, progesterone deficiency, history of trauma, and history of systemic diseases. Previous pregnancy or childbirth history, and the presence of immune system disease factors should also be ruled out. If there are many fetal factors, it is not suitable to actively maintain the fetus, so as to increase the chance of an abnormal baby being born.

5. Alcohol and cigarettes: Pregnant women smoking or inhaling secondhand smoke can cause low birth weight babies. Nicotine can increase the chance of miscarriage and premature birth, and make the fetus more prone to intrauterine distress. The newborn has low charm and is prone to disease. The deformed fetus caused by pregnant women drinking is called alcohol poisoning syndrome, and the poisoning is relatively mild and the symptoms are atypical, which is called ethanol-affected fetus. Therefore, pregnant women must quit smoking and drinking. If one spouse is addicted to alcohol, it may affect the quality of the fetus.

6. Common problems during early pregnancy include improper medication, or over-vaccination with rubella vaccine (live attenuated vaccine) in early pregnancy, carbon monoxide poisoning and other problems. Therefore, pre-pregnancy education should be strengthened to reduce some unfavorable conditions.