What are the symptoms of luteinization of ovarian follicles?

The syndrome of luteinized uncleaved follicle refers to the fact that the egg is perfect but not cleaved. The egg is not released but is originally sphingomyelinized, producing progesterone and secreting estrogen, and the body's organs undergo a series of changes similar to the ovulation cycle. The main clinical features are long menstrual cycles, close ovulation period but persistent infertility. It is a special type of anovulatory menstruation and one of the main causes of infertility.

In 1975, Jewelewicz first proposed the phenomenon of luteinization without rupture of ovarian follicles and named it LUFS. The treatment method varies from person to person, and is usually based on inducing ovulation. The most common way is to supplement growth hormone. If after using ovulation-inducing drugs, the follicles still do not rupture for several months, in vitro fertilization may be needed.

The cause of LUFS is not entirely clear. Most of them are related to factors such as disorder of nerve center regulation, local obstruction, and mental and psychological state. The prevalence rate varies from report to report, but most reports suggest that it is about 3% to 5% during the natural menstrual cycle, and about 30% to 40% during the drug-induced ovulation cycle. According to B-ultrasound dynamic detection, it can be divided into three types: small egg type, egg retention type and continuous expansion type.

Luteinization characteristics of follicles

Undeciphered sphingomyelination syndrome is a distinct form of utero-ovarian anovulatory menstruation. During the normal ovulation process, one of the ovaries in the uterus is fully developed, and it ruptures in the middle and late stages of the menstrual cycle to release the egg and produce progesterone at the same time. A large amount of estrogen is secreted in the early stage of ovulation, and a large amount of estrogen is secreted after ovulation. Under the action of estrogen and estrogens, the uterine wall changes from the reproductive phase to the metabolic phase; the cervical mucus changes from clear and transparent to thick and turbid; the body temperature during ovulation shows a biphasic characteristic. However, patients with uncleaved sphingomyelinosis syndrome have two characteristics:

The ovum shows signs of maturity, with peaks in estrogen and luteinizing hormone, but the mature follicle does not rupture or release the egg, it just continues to expand.

Luteinization of follicles

The unbroken egg produces progesterone, which metabolizes estrogen on the cervix and uterine wall; the body temperature during ovulation is biphasic.