There are small buds on the labia

If there is a small granulation on the edge of the labia, it must not be ignored, because if you ignore it, the condition will worsen and it will become more difficult to treat. As a result, some patients can only undergo systemic treatment and take medication every day. If there is no sign of improvement after taking these drugs for one or two courses, surgical treatment measures must be taken.

General treatment

Sexual activity should be prohibited during treatment.

Systemic therapy

(1) Choice of drugs: Tetracyclines, macrolides, ampicillin or aminoglycosides are effective for granuloma venereum.

(2) Treatment options:

① Sulfamethoxazole/trimethoprim (cotrimoxazole) 1.0g, orally, twice a day, for 3 to 4 weeks.

② Tetracycline 0.5g, orally, 4 times/day, for 3 to 4 weeks; or doxycycline (Doxycycline) 0.1g, orally, 2 times/day, for 3 to 4 weeks; or minocycline (Minocycline) 0.1g, orally, 2 times/day, for 3 to 4 weeks.

③ Erythromycin 0.5g, orally, 4 times/d, for 3 consecutive weeks; or roxithromycin 0.15g, orally, 2 times/d, for 3 consecutive weeks; or clarithromycin 0.5g, orally, 2 times/d, for 7-10 days; or azithromycin 0.25g, orally, 1 time/d, for 7-10 days, the initial dose is 1.0g.

④Streptomycin 1.0g, intramuscular injection, 2 times/d, for 10 consecutive days; or gentamicin 80,000 U, intramuscular injection, 2 times, for 3 consecutive weeks.

⑤Ampicillin can also be used. People who are allergic to penicillin can be treated with lincomycin.

⑥Norfloxacin (Florfloxacin), ciprofloxacin (Ciprofloxacin), azithromycin, and ceftriaxone (Ceftriaxone) are also used to treat granuloma venereum.

Topical treatments

Ulcers can be rinsed with potassium permanganate solution, saline or hydrogen peroxide solution, and then applied with antibiotic ointment. The dressing should be changed every day to keep the drainage unobstructed and the wound clean. Protective poultices can be applied around the ulcer to prevent autoinoculation.

Surgery

In the late stage when tissue destruction, scars and deformities have occurred, surgical treatment can be performed.

Treatment of sexual partners

Sexual partners who have had sexual contact with the patient in the past 3 months should receive preventive treatment, and if they have the same clinical manifestations, they should be treated at the same time.

Efficacy observation

The efficacy can be judged by whether the clinical manifestations are improved or whether Donovan bodies persist.

Antibiotics, especially oxytetracycline, tetracycline and streptomycin, are effective for granuloma venereum. The general course of treatment is no less than 10-15 days, 500 mg each time, 4 times a day. Penicillin is not effective. In the past, the prognosis was poor, but in modern times, due to the development and application of antibiotics, the prognosis has improved greatly.