Does fluconazole affect pregnancy?

Pregnant women should take medications with caution during pregnancy, because many drugs can be harmful to the fetus. Therefore, pregnant women must take medications as prescribed by their doctor to avoid affecting the health of the fetus. Fluconazole is a drug for treating throat and esophageal infections. It is effective for candidiasis and cryptococcosis. Many pregnant women do not know whether fluconazole will affect pregnancy. Does fluconazole have any effect on pregnancy? Let’s take a look at it next.

1. Does fluconazole affect pregnancy?

1. In animal experiments, when this product is given to animals at high doses, changes such as miscarriage, increased stillbirths, rib deformities in young animals, and cleft palate may occur. Although this has not been found in humans, pregnant women should not use it.

2. There is no data on the concentration of this product in breast milk, so lactating women should use it with caution or suspend breastfeeding when taking this product.

2. Indications of Fluconazole

1. Candidiasis: used to treat oropharyngeal and esophageal Candida infections; disseminated candidiasis, including peritonitis, pneumonia, urinary tract infections, etc.; Candida vulvovaginitis. It can also be used to prevent Candida infection in bone marrow transplant patients receiving cytotoxic drugs or radiotherapy.

2. Cryptococcosis: used to treat new cryptococcosis other than meningeal; in the treatment of cryptococcal meningitis, this product can be used as a maintenance therapy after the initial treatment with amphotericin B combined with flucytosine.

3. Coccidioidomycosis.

4. For the prophylactic treatment of patients receiving chemotherapy, radiotherapy and immunosuppressive therapy.

5. This product can also replace itraconazole for the treatment of blastomycosis and histoplasmosis.

3. Precautions for taking fluconazole

1. This product may cause cross-allergic reactions with other azole drugs, so it is contraindicated for patients who are allergic to any azole drug.

2. Since this product is mainly excreted by the kidneys, renal function should be checked regularly during treatment in patients with impaired renal function.

3. The course of treatment for this product should depend on the site of infection and individual treatment response. Generally, treatment should continue until the clinical manifestations of fungal infection and laboratory test indicators show that the fungal infection disappears. AIDS patients with cryptococcal meningitis or recurrent oropharyngeal candidiasis require long-term maintenance treatment with this product to prevent relapses.

4. For patients receiving bone marrow transplantation, if severe granulocytopenia has occurred in advance, this product should be used prophylactically until the neutrophil count rises to above 1×109/L for 7 days.

5. For patients with impaired renal function, the dosage can be adjusted according to the above scheme (see Dosage and Administration); hemodialysis patients can be given a daily dose of this product after each dialysis, because 3 hours of hemodialysis can reduce the blood concentration of this product by about 50%.