Why does the transplantation fail to implant?

Many infertile couples choose IVF because it is a more scientific method. If the woman has no uterine problems, she can also transplant the fertilized eggs cultivated by IVF into the uterus. However, some women may face the phenomenon of fertilized eggs not implanting. There are many reasons for this phenomenon. So what is the reason for multiple transplants without implantation?

When doing in vitro fertilization, it is inevitable to encounter various problems: poor ovulation induction effect, poor sperm and egg matching, poor embryo development, etc.

Among these, I think the most uncomfortable thing is the problem of embryo implantation - I myself have been troubled by this problem for a long time. Among seven transplants, four failed to implant and two were biochemical.

Especially when ovulation induction, egg retrieval, pairing, and cyst cultivation all go smoothly, you transplant with confidence again and again, only to be disappointed again and again. This feeling is really more torturous than not being able to retrieve eggs or pair good embryos in the first place.

In addition to myself, many sisters have left messages asking me what to do if in vitro fertilization fails to implant after multiple attempts. It seems that this situation is quite common in in vitro fertilization.

In the process of my continuous failure, I have searched for the reasons for the failure to implant countless times. In summary, the main reasons can be summarized into two categories: "seed" and "soil":

1. Poor embryo quality

Just like unhealthy seeds are difficult to germinate and grow, if the quality of the embryo is poor, it will directly affect its implantation and development.

Embryonic development is a dynamic process. Normally, the fertilized egg divides and develops. The embryos on the 1st to 3rd day are called cleavage-stage embryos, and they may develop into blastocysts on the 5th to 6th day. Embryologists score embryos based on the number of cells, the uniformity of the cells after division, and the degree of fragmentation.

In order to increase the success rate of embryo implantation, if a large number of eggs are retrieved, blastocyst culture is often performed. Compared with cleavage embryos cultured on the 3rd day, the implantation success rate of blastocysts cultured on the 5th day will be greatly improved. Blastocysts are divided into grades A, B, C, and D according to the inner cell mass and trophoblast cells.

Although there is a certain degree of subjectivity in judging the quality of embryos based on appearance, morphological scoring is currently the most commonly used method for selecting embryos and can basically match the clinical pregnancy outcomes.