What to do if ovarian failure occurs

The female ovary is a very important organ for women. When women get older, their ovaries will gradually weaken. When the ovarian function weakens, the female face will become more and more aged, and will age very quickly. Therefore, many women now pay great attention to the protection of their ovaries. If they want to stay young forever, their ovaries must not weaken. So what should they do if their ovaries weaken?

Premature ovarian failure refers to a situation in which a woman who once had a natural menstrual cycle develops ovarian atrophy before the age of 45, with a decrease in menstrual volume, shortened menstrual period, longer menstrual cycle, and even persistent amenorrhea. The causes may be infection, iatrogenic premature ovarian failure, idiopathic premature ovarian failure and immune factors.

At the same time, clinically, secondary sexual characteristics retract, and menopausal symptoms such as hot face, irritability, and susceptibility to colds occur; the woman is prone to catching colds, and her blood follicle-stimulating hormone level increases to more than 40 units, which is equivalent to the level of postmenopausal women; while her blood estradiol level is significantly low. Gynecological examination showed obvious atrophy of the internal reproductive organs and thin and congested vaginal mucosa. Ovarian biopsy was performed by laparotomy, and ovarian atrophy was observed. Microscopic examination showed that the ovarian cortex was filled with fibrous tissue, and no primordial follicles or other follicles of different levels were visible.

Many people blindly believe that the disease can be cured by supplementing hormones, which is wrong. First, estrogen supplementation cannot cure the root cause, it can only improve symptoms, not the function of the ovaries; second, long-term and large-scale estrogen supplementation will not only bring certain side effects to the body, but also put the ovaries in a "dependent" state. When the drug is stopped, the estrogen deficiency may become worse, and may even lead to worse ovarian function. Traditional Chinese medicine treatment: Traditional Chinese medicine believes that the pathogenesis of premature ovarian failure is related to insufficient kidney water and hyperactivity of liver yang. Insufficient kidney water often leads to a deficiency of Yin essence, which can lead to a series of Yin deficiency symptoms, such as hot face, irritability, restless sleep, tinnitus, etc. Yin deficiency often leads to Yang hyperactivity. The inability of kidney water to nourish liver wood will naturally lead to liver Yang hyperactivity. These pathogenesis also laid the foundation for TCM treatment of "seeking the root cause of the disease".

Patients with premature ovarian failure can recover their fertility function after systemic treatment once ovulation occurs. The following methods are currently used:

⑴ In the artificial cycle, take 0.25-1 mg/day of ethoprogesterone from the 6th day of the normal cycle for 20 consecutive days, and take 10 mg/day of medroxyprogesterone from the 16th to the 25th day of the cycle, or inject 20 mg of progesterone intramuscularly every other day from the 17th day of the cycle for 5 consecutive times.

⑵Gonadotropin: The author believes that patients with premature ovarian failure may have low biological activity of FSH and LH, and use large amounts of gonadotropin for treatment to achieve the purpose of follicular development, ovulation, and pregnancy. There are also reports of patients being treated with chlorpheniramine.

⑶ For patients with immunosuppressive agents, especially those with combined adrenal insufficiency or premature aging, in addition to the above artificial cycles, cortisol such as dexamethasone can be added for treatment, and there have been successful reports.

⑷ Treatment combining traditional Chinese and Western medicine: It has been reported that patients with hypergonadotropin-induced amenorrhea often suffer from renal yin failure and liver and kidney fire inflammation, and should be treated with the method of nourishing yin and reducing fire, and tonifying the kidney and activating blood circulation. Take one dose of medicinal Zhimu, Phellodendron, Tortoise Shell, Turtle Shell, Ligustrum Lucidum, Epimedium, Peach Kernel, Rehmannia Glutinosa, Red Peony Root, and Angelica Sinensis decocted in water daily. Use ethopropanol 0.5-1 mg/day for 20 days, and then continue taking the medicine after menstruation comes.

Chinese Medicine

Traditional Chinese Medicine's green dialectical therapy uses medication in stages according to the different changes in the menstrual cycle, endometrium, and ovaries. It combines traditional Chinese medicine's syndrome differentiation with Western medicine's disease differentiation, and provides personalized treatment mainly with traditional Chinese medicine. It not only takes into account the cyclical changes of the ovaries during the menstrual cycle, but also conforms to the changes of yin and yang in the body, maintains the characteristics of traditional Chinese medicine's inherent dialectical diagnosis and treatment and overall adjustment, and achieves outstanding therapeutic effects.