I took mifepristone and had stomach pain

Because mifepristone tablets are a contraceptive, many women take a morning-after pill to prevent pregnancy. Taking the contraceptive pill may cause women's menstruation to come early or postpone ovulation. However, some women have particularly strong physical reactions and feel abdominal pain after taking mifepristone tablets. What's going on? Let me give you a detailed introduction below.

It is a strong antiprogestin that can bind to progesterone receptors and glucocorticoid receptors. Its affinity for endometrial progesterone receptors is 5 times stronger than that of progesterone. It has an inducing effect on pregnant animals at all stages of pregnancy and can be used as a non-surgical anti-early pregnancy drug. There was no significant effect on cortisol levels at effective doses. Since this drug cannot induce sufficient uterine activity, the incomplete abortion rate is high when used alone to prevent early pregnancy. However, it can increase the sensitivity of the uterus to prostaglandins. Therefore, adding a small dose of prostaglandins can not only reduce the adverse reactions of prostaglandins, but also significantly increase the complete abortion rate (to more than 95%). This product has the effect of softening and dilating the cervix. Oral tmax is 1 to 3 hours, bioavailability is 70%, plasma protein binding rate is 98%, and elimination t1/2 is about 18 hours. Vaginal bleeding usually begins 30 hours after oral administration and lasts for 1 to 16 days.

In addition to being used to prevent early pregnancy, induce menstruation and stop pregnancy, and induce labor for intrauterine fetal death, it is also used in gynecological surgical operations, such as the placement and removal of intrauterine contraceptive devices, taking endometrial specimens, laser separation of cervical canal developmental abnormalities, and cervical dilation and curettage.

(1) Those who have severe reactions, nausea, and frequent vomiting during early pregnancy should not use this product to avoid aggravating the reaction.

(2) For those diagnosed with early pregnancy , the duration of amenorrhea should not exceed 49 days. The shorter the pregnancy period, the better the effect.

(3) When this drug is used sequentially with prostaglandins to prevent early pregnancy , a small number of women may experience incomplete abortion, which can cause heavy bleeding. Therefore, it must be used under the supervision of a doctor and treated in a timely manner.

(4) After taking the medicine , a small amount of vaginal bleeding will generally occur. A few women have miscarriages before taking prostaglandins. About 80% of pregnant women expel the chorionic foetal sac within 6 hours after taking prostaglandins, and about 10% of pregnant women expel the foetal sac within one week after taking the medicine.

(5) The patient should see a doctor 8 to 15 days after taking the medicine to determine the abortion effect. If necessary, an ultrasound examination or measurement of human chorionic gonadotropin (HCG) can be performed. If the diagnosis is a failed or incomplete abortion, a vacuum aspiration procedure should be performed to terminate the pregnancy or clean the uterine cavity.

(6) All doctors or patients performing abortion surgery should consider carefully before using this product because it may have some special risks, such as sepsis.

(7) Because this product must be used sequentially with prostaglandins , it is not suitable for patients with contraindications to prostaglandins, such as glaucoma, asthma, and allergic constitution.

Pregnant women over 35 years old and smokers should avoid using it.