Changes of hcg during menstruation after hydatidiform mole curettage

Speaking of HCG, I believe everyone is not very clear about it. This is human chorionic gonadotropin, a glycoprotein secreted by the trophoblast cells of the placenta. If the human body is pregnant, the concentration in the body will increase significantly, which is also a sign of pregnancy. After uterine curettage of molar pregnancy, the HCG value will decrease, which means that the curettage was successful. So, let's talk about the changes in HCG during uterine curettage of molar pregnancy and menstruation.

Judging from the changes in blood HCG after hydatidiform mole curettage, as long as it is on a downward trend overall, it is okay. Regular review is recommended.

Generally, blood hCG levels decrease after medication treatment for hydatidiform mole. So, what should we do if the hCG level of hydatidiform mole rises? Under normal circumstances, after the hydatidiform mole is emptied, the serum hCG will steadily decrease. The average time for the first drop to normal is 9 weeks, and the longest time is no more than 14 weeks. If hCG remains abnormal after the mole is evacuated, gestational trophoblastic tumor should be considered. High-risk hydatidiform mole should be considered when the following high-risk factors are present: hCG>100,000U/L; the uterus is significantly larger than the corresponding gestational age; the diameter of the ovarian luteinized cyst is>6 cm or bilateral luteinized cysts; age 40 years old; small hydatidiform mole; history of repeated hydatidiform mole; pregnancy complications: hyperemesis gravidarum, hyperthyroidism, etc.

There is a 10% to 20% chance of malignant transformation in patients with hydatidiform mole, so patients with hydatidiform mole should be followed up regularly. In particular, following up the changes in HCG in urine or blood can help detect malignant tendencies at an early stage, which is particularly important for the prognosis of the disease. After hydatidiform mole curettage, urine must be checked once a week until the urine pregnancy test is negative, then once a month, and once every 3 months after 6 months, with at least 2 years of follow-up. The patient can become pregnant again only after completing the follow-up.

To prevent the recurrence of hydatidiform mole, it is important to pay attention to follow-up after treatment. After evacuation of hydatidiform mole, hCG should be measured once a week until 3 consecutive negative results, and then once a month for at least half a year. Thereafter, follow-up can be conducted every six months for a total of 2 years. During follow-up, special attention should be paid to changes in hematuria and HCG. Gynecological examinations should also be performed to understand the state of uterine involution and to note whether the patient has abnormal vaginal bleeding, hemoptysis, or other symptoms of metastatic lesions. Pelvic ultrasound, chest X-ray or CT examination are also performed.