What is the reason for high D2 aggregates in pregnant women

D-dimer is an indicator for detecting thrombosis. Generally, it has little impact on women during pregnancy, and it generally does not cause adverse effects on the fetus. However, it should be noted that if this index is high, you must be vigilant. Deep vein thrombosis in the lower limbs may occur, which is relatively harmful to pregnant women. At this time, a color ultrasound examination can be performed. If the D2 polymer reaches more than 4000, then the blood in the body is in a high state, which can easily lead to cerebral infarction or myocardial infarction. During this period, timely medication should be used. Aspirin can be taken, which can effectively reduce the risk of myocardial infarction or cerebral infarction. In addition, the specific cause must be found.

Clinical significance

1. D-dimer originates from cross-linked fibrin clots dissolved by plasmin and mainly reflects the fibrinolytic function. The clinical detection of D-dimer is mainly used in the diagnosis of venous thromboembolism (VTE), deep vein thrombosis (DVT) and pulmonary embolism (PE).

2. Increase: seen in secondary hyperfibrinolytic function, such as hypercoagulable state, disseminated intravascular coagulation, kidney disease, organ transplant rejection, thrombolytic therapy, etc.

3. Myocardial infarction, cerebral infarction, pulmonary embolism, venous thrombosis, surgery, tumors, disseminated intravascular coagulation, infection and tissue necrosis can also lead to elevated D-dimers.

Precautions

(1) D-dimer can distinguish primary fibrinolysis from secondary fibrinolysis. In primary fibrinolysis, D-dimer is not elevated. (2) Under normal circumstances, the D-dimer level in the elderly is higher than that in young people.

Normal value

FDP in serum <1mg/L D-dimer in plasma 20-400μl This value is for reference only, the specificity of each kit must be considered.

Plasmin can break down fibrinogen and fibrin, and this enzyme is the key enzyme in fibrinolysis. Therefore, the determination of fibrinogen and fibrin degradation products is a hallmark indicator of increased fibrinolysis (hyperfibrinolytic state). Usually fibrin is cross-linked on the blood vessel wall under the action of factor XIIIa. This cross-linked fibrin generates specific D-dimers when cleaved.