What's wrong with the shortened menstrual cycle? It may be endocrine disorder

Generally speaking, the normal menstrual cycle is an average of 28 days, which means that normal menstruation is cyclical. Many people don’t know why the menstrual cycle is shortened. This situation may be related to physical abnormalities or may be caused by endocrine system disorders.

1. Caused by neuroendocrine dysfunction

The main problem is that the function of the lower hindbrain-stomach-ovary axis is unstable or defective, that is, menstrual disease.

2. Caused by organic disease or drugs

Including local inflammation, tumors and developmental abnormalities, malnutrition of the reproductive organs; intracranial diseases; other endocrine dysfunctions such as thyroid and adrenal cortex dysfunction, diabetes, Sheehan's disease, etc.; liver diseases; blood diseases, etc. Menstrual irregularities may occur in women who use drugs to treat mental illnesses, endocrine preparations, or intrauterine devices for contraception. Certain occupations, such as long-distance runners, are prone to amenorrhea. In addition, some abnormal bleeding during pregnancy is often mistaken for menstrual irregularities.

3. Neurotransmitters

Relevant neuroendocrine studies have shown that hypothalamic neurotransmitters such as opioid peptide (EOP), epinephrine (NE) and dopamine (DA) are significantly correlated with the occurrence of hot flashes. Serotonin (5-HT) has regulatory functions on endocrine, cardiovascular, emotional and sexual life. It has been reported that autonomic dysfunction in patients with perimenopausal syndrome is associated with a significant decrease in blood 5-HT. Animal experiments further demonstrated that the 5-HT level in the hypothalamus was significantly reduced after oophorectomy, and this could be significantly reversed after the use of estrogen. Therefore, it is believed that the functional disorder symptoms manifested by perimenopausal syndrome may be related to the decrease in 5-HT with age. Studies have found that the levels of beta-endorphin (β-EP) and its antibodies in the blood of postmenopausal women are significantly lower than those in women of the reproductive period. The decrease in β-EP antibodies indicates that the immune system's function in regulating neuroendocrine function is disrupted, resulting in various neuropsychiatric symptoms.