Causes of PCOS

Polycystic ovary syndrome is a common disease among infertile women. Because the disease can cause ovulation disorders in women, many women with polycystic ovary syndrome cannot become pregnant normally. Clinically, it has been found that polycystic ovary syndrome not only causes infertility, but may also cause endocrine disorders in women, causing hirsutism and acne, which has a relatively serious impact on women's lives. Therefore, understanding the cause of polycystic ovary syndrome and carrying out targeted treatment are the key for patients to get rid of polycystic ovary syndrome.

The cause of PCOS is still unclear, and the pathological mechanisms involved are very complex. It is generally believed to be related to dysfunction of the hypothalamus-pituitary-ovarian axis, adrenal dysfunction, genetics, metabolism and other factors.

1. Genetics

PCOS is an autosomal dominant, X-linked (sex-linked) inheritance, or a disease caused by gene mutation. The chromosome karyotype of most patients is 46,XX, and some patients show chromosome aberration or mosaicism such as 46,XX/45,XO/46,XX/46,XXq and 46,XXq.

2. Adrenarche hypothesis

PCOS originates from prepubertal adrenal disease, that is, when subjected to strong stress stimulation, the zona reticularis secretes too much androgen, which is converted into estrogen outside the gonads, feedback-induced disturbances in the GnRH-GnH release rhythm of the HP axis and an increase in the LH/FSH ratio, which subsequently causes increased ovarian androgen production, that is, the adrenal glands and ovaries jointly secrete more androgen, leading to hyperandrogenemia. Hyperandrogenism causes thickening of the ovarian capsule fibrosis, inhibits follicular development, and causes ovarian cystic enlargement and chronic anovulation.

Traditional Chinese medicine believes that this disease is mainly caused by kidney deficiency, phlegm and dampness, qi stagnation and blood stasis, damp heat in the liver meridians, etc., which lead to dysfunction of the kidney-tiangui-chongren-uterus axis, resulting in amenorrhea and infertility.

This article has analyzed the causes of polycystic ovary syndrome. Patients need to pay attention when treating the disease. The treatment of polycystic ovary syndrome is relatively complicated and requires long-term attention and treatment. Therefore, it is recommended that patients must have enough confidence, especially women who have not yet given birth must pay enough attention to the disease.