Causes of positive anti-endometrial antibodies

I believe that everyone is quite unfamiliar with anti-endometrial antibody positive in life. This disease will lead to female infertility after most of the time. This disease can be divided into positive or negative. Once it occurs, it will even lead to very serious consequences. But how does anti-endometrial antibody positive come about? How can we discover this disease in life? The following article describes the causes of this disease.

Anti-endometrial antibodies are autoantibodies that use the endometrium as target antigen and induce a series of immune responses. Reports have shown that the positive rate of anti-endometrial antibodies in the blood of women with endometriosis and infertility is significantly higher than that of normal controls. In the serum of endometriosis, the detection rate of EMAb can reach 70%-80%.

Causes:

Clinical studies have shown that ectopic endometrium is antigenic and can induce the body to produce anti-endometrial antibodies. When antigen and antibody combine, they can be deposited in the endometrium and ectopic lesions, destroying the endometrial structure by activating complement. Electron microscopy revealed endometrial hypoplasia, vacuoles in endometrial glands and basement membrane, and a decreased ratio of ciliated to non-ciliated cells. The endometrium shows insufficient secretion, which is not conducive to the implantation of fertilized eggs, thus leading to infertility and recurrent miscarriage.

There are two aspects to the production of anti-endometrial antibodies: on the one hand, it is because of the stimulation system of ectopic endometrium; on the other hand, it is because of the abnormal immune system of the body (autoimmune deficiency).

Ectopic endometrium is antigenic and can induce the body to produce anti-endometrial antibodies. When antigen and antibody combine, they can be deposited in the endometrium and ectopic lesions, destroying the endometrial structure by activating complement.

During the curettage of artificial abortion, the embryonic sac may also act as an antigen to stimulate the body to produce antibodies.

When a woman's endometrium is inflamed, it may also be converted into antigens or haptens, stimulating the body to produce corresponding antibodies.

The above article introduces the causes of anti-endometrial antibody positive disease to women. I believe everyone has some understanding of this disease, so you can prevent the occurrence of this disease in advance in your life. In your daily diet, you should eat more light and easy-to-digest foods, arrange your life and work time well, and combine work and rest.