Factors affecting pituitary prolactinoma

I believe everyone must know the important role of the pituitary gland in our human body. If there is a problem with our pituitary gland, it will not only cause various diseases to our body, but may even lead to our death. Therefore, once we find out that there is a genetic problem with the pituitary gland, we must deal with it in time. Pituitary prolactinoma is a type of pituitary disease, so what exactly causes the occurrence of pituitary prolactinoma? Below we introduce the influencing factors of pituitary prolactinoma.

1. Nerve stimulation: Irritation of certain parts of the skin, especially the chest, including severe pain caused by peripheral nerve damage, can be transmitted to the hypothalamus through nerves and cause an increase in prolactin. Such as chest surgery, burns, shingles on the chest and back, etc.

2. Pituitary disorders: mainly various tumors in the pituitary area. In addition, some cases of empty sella syndrome and hyperpituitarism can also cause galactorrhea and amenorrhea.

3. Drug factors: Sedatives that act on the central nervous system, such as chlorpromazine, morphine, etc., can reduce the content of catecholamines in the hypothalamus, thereby reducing the activity of prolactin-releasing factor produced by the hypothalamus. Antihypertensive drugs such as methyldopa and reserpine can inhibit the release of prolactin inhibitory factor. Metoclopramide can stimulate excessive secretion of prolactin from the pituitary gland.

4. Primary hypothyroidism: When the thyroid function is hypothyroid, the information of insufficient thyroid secretion is transmitted to the hypothalamus through feedback, causing the hypothalamus to produce a large amount of thyrotropin-releasing factor. This factor, while stimulating the pituitary gland to secrete thyroid-stimulating hormone, can also stimulate the excessive secretion of pituitary prolactin and cause galactorrhea.

5. Hypothalamic disorders: Diseases of the hypothalamus and adjacent areas, such as encephalitis, craniopharyngeal tumor, pineal tumor, partial hypothalamic infarction, pseudotumor cerebri, pituitary stalk transection, etc., can cause a decrease in prolactin-inhibiting factor produced by the hypothalamus, or an increase in prolactin-releasing factor and thyroid-stimulating hormone-releasing factor. The former can cause prolactin to be produced blindly due to the loss of inhibition, while the latter two directly promote the increase of prolactin production.

In the above article, we introduced what the pituitary gland is. We know that the pituitary gland plays a very important role. Pituitary prolactinoma is a type of pituitary disease. Pituitary prolactinoma is very harmful, so we must pay attention to this disease. The above article introduces the influencing factors of pituitary prolactinoma in detail.