New breakthrough! Artificial liver technology "transfusion" saves lives, sepsis patients regain new life!

Recently, the ICU technology of the Second Emergency Department of Hunan Provincial People's Hospital has made another breakthrough, and the hospital's first stand-alone plasma filtration adsorption technology (CPFA) has been successfully carried out, marking that the hospital's critical care blood purification integrated technology has reached a new level and has important driving significance for the development of critical care technology.

A week ago, the ICU of the Second Emergency Department admitted a patient with sepsis, including septic shock, severe pneumonia, type I respiratory failure, renal insufficiency, coagulation dysfunction, water and electrolyte metabolism disorder, etc. After sufficient communication between doctors and patients, the ICU team implemented continuous plasma filtration adsorption technology, anti-infection, component blood transfusion, nutritional support, and maintenance of electrolyte balance for the patient.

After completing the treatment for the day, the blood test results showed that the inflammatory response sensitive indicator interleukin 6 decreased from 25125pg/ml to 402pg/ml, while coagulation function, renal function and water and electrolytes were significantly improved.

Jing Yingxia, deputy chief physician of the Second Emergency Department , introduced that CPFA is an advanced and complex integrated blood purification technology at home and abroad. From the perspective of integrated composition, two machines are usually required to combine the two modes of blood filtration and plasma adsorption. At present, through the new technology project of our hospital, plasma filtration adsorption (only one CRRT machine is needed to complete the project), it is a new breakthrough in the hospital's artificial liver technology after the development of plasma exchange (TPE), dual plasma molecular adsorption (DPMAS), plasma diafiltration (PDF) and other artificial liver technologies.

This mode has obvious advantages over conventional hemoperfusion + hemofiltration dialysis. Blood cells and platelets do not need to directly contact the adsorbent, which not only avoids damage to blood cells, platelets and coagulation factors and reduces the risk of bleeding, but also can absorb more harmful substances and inflammatory factors in the body than hemoperfusion, and can adjust the water and electrolyte balance.

This technology has significant therapeutic effects on liver failure, sepsis, septicemia, severe pancreatitis (non-hyperlipidemic), multiple organ failure, acute respiratory distress syndrome, and acute renal failure. The successful implementation of this technology has brought hope of life to patients.

Hunan Medical Chat Special Author: Zhou Yuan, Emergency Department 2, Hunan Provincial People's Hospital

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(Edited by YT)