Oral diseases caused by taking medicine (IV) - Aphthous oral ulcers

Many people are familiar with oral ulcers. The most common type of oral ulcer in life is recurrent aphthous ulcer, also known as recurrent aphthous ulcer. It is one of the common oral mucosal diseases with unknown etiology and is prone to recurrence.

Unlike recurrent aphthous ulcers, drug-induced oral ulcers, aphthous-like oral ulcers, have relatively clear causes. When the underlying cause is effectively controlled, these ulcers will disappear. There are several types of drugs that may cause drug-induced oral ulcers.

1 Nonsteroidal anti-inflammatory drugs

Nonsteroidal anti-inflammatory drugs (NSAIDs) were the first class of drugs found to be associated with aphthous oral ulcers. Piroxicam , which may contain a thiol group, can cause this type of ulcer. In addition, naproxen and rofecoxib are also associated with the occurrence of aphthous oral ulcers.

2 Mammalian target of rapamycin inhibitors

Patients with metastatic disease treated with mammalian target of rapamycin (mTOR) inhibitors , such as sirolimus , temosilimus , everolimus, and lidaformolimus, develop aphthous oral ulcers. Unlike idiopathic recurrent oral ulcers, these ulcers resolve completely without recurrence after cessation of treatment.

Source: References

3 Conventional chemotherapy drugs

Conventional chemotherapy drugs, such as 5- fluorouracil , cisplatin , methotrexate , and hydroxyurea, are orotoxic and can cause oral ulcers and ulcerative mucositis. These ulcers tend to be larger and more diffuse, and their appearance differs from the oval, well-defined, recurrent aphthous ulcers.

4 Other drugs

Mycophenolate mofetil has been reported to cause ulcers on the tongue, palate, lips, and gums of solid organ transplant recipients, but these ulcers resolve after discontinuation of the drug, as with tacrolimus. Rare cases of ulcers associated with multitargeted kinase inhibitors (MTKIs) have also been reported.

In addition, trimethoprim-sulfamethoxazole (Compound Xinruoming) and losartan (angiotensin receptor blocker antihypertensive drug ) are also related to the occurrence of aphthous oral ulcers.

References

[1] Yuan A, WooSB. Adverse Drug Events in the Oral Cavity[J]. Dermatol Clin, 2020, 38(4): 523-533.