Know a little about “medicine” | Which medicines cannot be taken together?

Aunt Li has been taking simvastatin to regulate blood lipids. Recently, she took erythromycin because of a cold. After a few days, she felt muscle aches all over her body and came to the hospital for treatment. The doctor said it was caused by drug interaction. Fortunately, she went to the doctor early, otherwise it would be dangerous. Aunt Li was puzzled. Could drug interaction be so serious?

Some drug interactions are very dangerous and sometimes life-threatening. For example: statins + antibiotics (such as roxithromycin, clarithromycin, etc.). The combination of the two can significantly increase the blood concentration of statins and induce rhabdomyolysis, just like Aunt Li's whole body muscle aches, and phosphokinase and blood creatinine will increase significantly, and in severe cases, acute renal failure can be caused. Warfarin + antibiotics. Warfarin mainly exerts its anticoagulant effect by inhibiting the production of active vitamin K, while antibiotics will cause a decrease in the synthesis of vitamin K in the body. The combination of the two can increase the international normalized ratio (INR), thereby inducing bleeding. 5-type phosphodiesterase (PDE-5) inhibitors (such as sildenafil for the treatment of male erectile dysfunction) + nitrates (such as isosorbide mononitrate). The combination of the two can cause hypotension and, in severe cases, shock.