If tachycardia occurs after taking dipine, take Lol to counteract it. Be careful not to reduce the dosage too quickly.

A friend with high blood pressure told Huazi that after taking dihydropyridine, his blood pressure was well controlled, but he developed tachycardia and palpitations, so the doctor added loratadine to control his heart rate. He asked Huazi what should be paid attention to when using these two antihypertensive drugs together, and if the heart rate is normal, can the loratadine be reduced?

Hua Zi said that dihydropyridines can cause the heart rate to increase, but this usually only occurs in the early stages of medication. After combined use with lolamines, if the heart rate is normal and blood pressure is low, you can consider reducing the dosage of lolamines, but do it slowly to guard against the "rebound after drug withdrawal" phenomenon.

1. Why do dihydropyridine drugs cause tachycardia? Dihydropyridine drugs are classified as dihydropyridine calcium channel blockers (CCBs) in pharmacology. They can inhibit the entry of calcium ions into vascular smooth muscle cells, reduce the excitability of vascular smooth muscle cells, and cause vasodilation. Simply put, dihydropyridine drugs can dilate blood vessels and lower blood pressure.

Dihydrotestosterone is a strong drug that can lower blood pressure, but the human body has already adapted to the state of high blood pressure. When blood pressure drops suddenly, the neural feedback system will be activated, reflexively causing sympathetic nerve excitement, which in turn causes cardiac excitement and increases the heart rate. Therefore, when using dihydrotestosterone, adverse reactions such as palpitations and tachycardia are prone to occur.

2. Lolamine drugs can lower heart rate Lolamine drugs are classified as β-receptor inhibitors in pharmacology. There are β1 receptors in the human heart. After being inhibited by drugs, the excitability of the heart decreases, the myocardial contractility weakens, the heart rate slows down, and ultimately reduces cardiac output and lowers blood pressure.

Therefore, from the pharmacological point of view, the combined use of lolamines and dihydrotestosterone can not only produce a synergistic effect to increase the antihypertensive effect, but also produce a complementary effect. Lolamines can slow down the heart rate and counteract the adverse reactions of dihydrotestosterone caused by tachycardia. It is a commonly used combination of antihypertensive drugs.

3. The dosage of Lolamine drugs should be reduced slowly. The tachycardia caused by diazepam drugs usually occurs in the early stage of medication. With continuous medication, when blood pressure is stabilized at a normal level for a long time, the human body will gradually adapt to the new blood pressure range, and the neural feedback after taking the medicine will not be very obvious, and the symptoms of tachycardia will weaken or disappear.

If bradycardia or low blood pressure occurs when the two drugs are used together, you can consider reducing or stopping the drug under the guidance of a doctor. However, it should be noted that when the dosage of the drug is suddenly reduced or stopped, there may be a "rebound" phenomenon, which is manifested as a sudden increase in heart rate and blood pressure, which may induce cardiovascular and cerebrovascular diseases.

The reason for this phenomenon is that long-term use of Lolamine drugs inhibits the β1 receptors on the heart, which increases the number and sensitivity of β1 receptors. When Lolamine drugs are suddenly stopped, the heart overreacts to the body's endogenous catecholamine hormones, causing blood pressure to worsen.

Therefore, when stopping taking Lol drugs, a slow process is required. The specific method is to reduce the dose of Lol drugs by half every 3 days until it is reduced to the lowest therapeutic dose, and then continue to take it for 4 days, and then stop the drug. Usually the entire reduction and discontinuation process takes no less than 2 weeks. If blood pressure fluctuates or rises again during the reduction period, it is recommended to consult a doctor to decide whether the reduction can continue.

To summarize, dihydrotestosterone may cause reflex tachycardia, while loratadine can slow down the heart rate. When the two drugs are used together to treat hypertension, the incidence of adverse reactions can be reduced. If the blood pressure is low and the heart rate is too slow, and the dose of loratadine needs to be reduced, be careful to reduce the dose slowly to avoid the "drug withdrawal rebound" phenomenon. Drugs should be used under the guidance of a doctor. If you have any questions about medication, please consult a doctor or pharmacist. I am pharmacist Huazi. Welcome to follow me and share more health knowledge.