People who blush when drinking alcohol are more likely to develop stomach cancer!

People who blush when drinking alcohol are more likely to develop stomach cancer!

Recently, a study published in Science Advances showed that people who blush when drinking have a greater risk of stomach cancer caused by drinking.

The researchers sequenced the genomes of 531 patients (319 Asians and 212 non-Asians) with gastric cancer.

The study found that a subtype of gastric cancer has a distinct alcohol-related mutational signature and strong Asian specificity, which is almost entirely attributed to drinking, smoking, and Asian-specific ALDH2 allele defects.

Among this group of patients, 70% carry the ALDH2 gene mutation, more than 90% are Asians, and the average alcohol consumption of this group of patients is not high.

This means that patients with ALDH2 gene mutations have a significantly increased risk of gastric cancer even if they only drink small amounts of alcohol.

Specifically, approximately one fifth of diffuse-type gastric cancers can be attributed to alcohol intake and either ALDH2 allele mutation or deletion or CDH1 variants.

As we all know, ALDH2 is one of the most important enzymes in the body's alcohol metabolism. People who carry the ALDH2 gene break down ethanol about 13 times faster than other people.

People with loss-of-function mutations in the aldehyde dehydrogenase gene ALDH2 metabolize acetaldehyde more slowly, their faces turn red when they drink, and they have poor alcohol tolerance.

Nearly 40% of the Chinese population has ALDH2 gene mutations. If the ALDH2 gene is mutated or missing, the activity of the corresponding protease will be greatly reduced, causing acetaldehyde to accumulate in the body for a long time and unable to be metabolized, which in turn causes capillary dilation, skin flushing and inflammation, which is the so-called "face flushing after drinking".

Source: Suzuki A, Katoh H, Komura D, et al. Defined lifestyle and germline factors predispose Asian populations to gastric cancer. Sci Adv. 2020;6(19):eaav9778. Published 2020 May 6. doi:10.1126/sciadv.aav9778.

Reprint: Please indicate "China Circulation Magazine"

<<:  What does Kung Pao mean in Kung Pao Chicken? How long should Kung Pao Chicken be marinated?

>>:  The epidemic is not over during the dog days of summer, and it will cause more trouble in autumn and winter?

Recommend

What does phv52 positive mean

HPV is the general name for human papillomavirus ...

The truth behind the "cursed" family is shocking!

Grandfather, father, uncle, and 27-year-old siste...

There are tips for healthy running, and rehabilitation can help you

In today's society, the country vigorously ad...

Will a girl's breasts still develop at 17?

In today's society, it seems that men pay mor...

Symptoms of gonorrhea in women

Gonorrhea is the most common disease of the urina...

How to deal with body odor during pregnancy

Body odor is a physiological phenomenon that grea...

Can facial scraping be done every day?

Many people pay more attention to their image and...

What are the physical symptoms of normal menstruation?

Menstruation refers to the periodic shedding and ...

Acne under the breast

Acne under the breasts may be caused by symptoms ...

Why do some people not stay up late to watch football?

Recently, watching the World Cup has become a mus...

When is the safe period to avoid pregnancy?

Women cannot get pregnant at all times. They can ...

Is the chance of threatened miscarriage high?

For pregnant women with a higher risk of miscarri...