Side effects of zoledronic acid

Side effects of zoledronic acid

People with bone disease are treated with zoledronic acid. Because it has a high affinity with bones, it can help the body inhibit the growth of bone cells and ultimately treat bone-related diseases. Although zoledronic acid is powerful, it is a drug after all, and it will cause certain side effects to the human body. The most common side effect is fever, but it will subside quickly. In addition to the side effect of causing fever, zoledronic acid has other side effects. The side effects of zoledronic acid are introduced in detail.

The most common side effect of zoledronic acid is fever. Other side effects include:

1. Systemic reactions: fatigue, chest pain, leg edema, conjunctivitis; 2. Digestive system: nausea, vomiting, constipation, diarrhea, abdominal pain, dysphagia, anorexia; 3. Cardiovascular system: hypotension; 4. Blood and lymphatic system: anemia, hypokalemia, hypomagnesemia, hypophosphatemia, hypocalcemia, granulocytopenia, thrombocytopenia, pancytopenia; 5. Muscle and bone: bone pain, joint pain, muscle pain; 6. Kidney: increased creatinine value in serum (related to the time of administration); 7. Nervous system: insomnia, anxiety, excitement, headache, lethargy; 8. Respiratory system: dyspnea, cough, pleural effusion.

Side effects of zoledronic acid also include urinary tract infection, upper respiratory tract infection, anorexia, weight loss, dehydration, flu-like symptoms (including fatigue, chills, malaise and facial flushing), redness and swelling at the injection site, rash, itching, etc. It occurs in about 1/3 of patients. The most common adverse reactions were flu-like symptoms (approximately 9%), including bone pain (9.1%), fever (7.2%), fatigue (4.1%), chills (2.8%), and arthralgia and myalgia (approximately 3%). Most of the side effects of zoledronic acid are mild and transient, and in most cases they will disappear automatically within 24 to 48 hours without special treatment.

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