What is the reason for delayed development of female reproductive organs?

Generally speaking, if a female friend does not have symptoms of puberty at the age of 16 and has not reached menarche at the age of 18, it is possible that her reproductive organs are underdeveloped, which is directly related to her overall development. The common causes of delayed development include genetic factors, malnutrition, chronic diseases, etc., so it is best for patients to undergo a detailed examination.

1. Causes of disease

1. Constitutional or idiopathic puberty retardation: There is no identifiable cause of the retardation, but the patient may eventually develop normally and has a family tendency.

2. Pathological developmental delay is caused by systemic malnutrition, chronic diseases, chemotherapy during adolescence, mental trauma, depression or adolescent endocrine diseases. It is caused by pineal tumors and is rare in women.

2. Pathogenesis

Delayed puberty is caused by a lack of estrogen in the body, which can be caused by the ovaries, the hypothalamus that regulates ovarian function, or the functional state of the pituitary gland. Because the mechanism that initiates puberty is still unclear, the pathogenesis of constitutional developmental delay has not been elucidated either. However, similar to precocious puberty, factors such as genetic factors, environment, and general health status are related to the onset of the disease.

1. Nutritional factors

Menarche is related to the amount of body fat. Menarche occurs when body fat increases to 17% of body weight. Menarche is delayed when body weight is too low, adolescents suffer from anorexia nervosa, or when high-intensity training causes weight loss.

2. Hypothyroidism

Pronunciation is often delayed, which is related to low systemic metabolism.

3. Pineal Tumor

Increased melatonin production affects the secretion of gonadotropin, causing developmental delays or hypogonadism.