What is the cause of corpus luteum deficiency?

What is the cause of corpus luteum deficiency?

Corpus luteum insufficiency is also known as corpus luteum dysfunction, which is very harmful to women. The most obvious harm is female infertility. There are many reasons for this disease. If the ovarian development function is incomplete, it is easy to cause such symptoms. In addition, ovarian ectopicness and supernumerary ovaries are prone to cause corpus luteum insufficiency. At this time, good treatment should be carried out in time. You can supplement progesterone, pay attention to dietary conditioning, etc.

Ovarian insufficiency

Primary ovarian dysgenesis mostly occurs in women with sex chromosome abnormalities, with 45K being the most common, and is usually bilateral. The ovaries are elongated, pale white, hard, cord-like, and accompanied by other deformities. There may be unilateral ovarian hypoplasia, often accompanied by ipsilateral fallopian tube or even kidney agenesis, and a unicornuate uterus may also appear on the affected side.

Ovarian ectopic

The ovaries are blocked in development and remain in the embryonic position instead of descending into the pelvic cavity. That is, they are located higher than the normal ovarian position, such as near the lower pole of the kidney or in the retroperitoneal tissue space, often accompanied by ovarian hypoplasia. If it descends too far, it may be located within the inguinal hernia sac.

Extra ovaries

The occurrence of a third ovary is extremely rare and may be far away from the normal ovary and not connected to the nearby infundibulopelvic ligament, utero-ovarian ligament, or broad ligament. During the embryonic period, an abnormality occurs in a certain area of ​​the renal ridge, and the third ovary is derived from this primordium that is separated from the normal one. It is often accompanied by cystic teratoma or mucinous cystadenoma. If a third ovary or accessory ovary is accidentally discovered, it should be removed like ectopic ovarian tissue.

Causes of luteal insufficiency include:

1. Relative deficiency of follicle-stimulating hormone, such as hyperprolactinemia and polycystic ovary syndrome.

2. Excessive levels of estrogen and progesterone during the menstrual cycle produce abnormally strong negative feedback inhibition, such as controlled superovulation.

3. Granulosa cell hypoplasia, such as polycystic ovary syndrome, clomiphene-induced ovulation during menopause.

4. Loss of granulosa cells, such as egg extraction during assisted reproductive technology.

5. Systemic cell metabolism problems, such as hypothyroidism.

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