The harm of high prolactin, these changes in the body have a great impact

High prolactin level, also known as hyperprolactinemia in clinical practice, has a great impact on women. It can cause menstrual irregularities, the most common of which is amenorrhea and oligomenorrhea. It can also lead to infertility, vision loss, and blindness, and requires timely treatment.

(1) Menstrual disorders: primary amenorrhea accounts for 4%, secondary amenorrhea accounts for 89%, oligomenorrhea accounts for 7%, and dysfunctional bleeding and luteal insufficiency account for 23% to 77%.

(2) Galactorrhea The incidence of typical amenorrhea-galactorrhea syndrome is 20.84% ​​in non-tumor type hyperprolactinemia, 70.6% in tumor type, and 63% to 83.5% in simple galactorrhea. Galactorrhea may be overt or occur when the breast is compressed and may be watery, serous, or milky. Breasts are mostly normal.

(3) The incidence of infertility is 70.7%, which can be primary or secondary infertility and is related to anovulation, luteal insufficiency or luteinized unruptured follicle syndrome (LUFS).

(4) Hypoestrogenemia and hyperandrogenism: Decreased estrogen levels can cause hot flashes, palpitations, spontaneous sweating, vaginal dryness, dyspareunia, and decreased libido. Elevated androgens cause moderate obesity, seborrheic dermatitis, acne, and hirsutism.

(5) Changes in vision and visual field: When pituitary tumors involve the optic chiasm, they can cause decreased vision, headaches, dizziness, hemianopsia and blindness, as well as functional impairment of cranial nerves II, III and IV, and fundus edema and exudation.

(6) Acromegaly: seen in PRL-GH adenoma, myxedema seen in combined hypothyroidism, some patients have type 2 diabetes and osteoporosis.